Assay Detail
Binding
CHEMBL4049704
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of 26S proteasome regulatory subunit RPN11 deubiquitinating activity in human erythrocytes using Ub4-pepOG protein substrate preincubated for 1 hr followed by substrate addition measured after 80 mins by fluorescence polarization assay
50
Total Activities
50
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
26S proteasome non-ATPase regulatory subunit 14 (CHEMBL2007629) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of an Inhibitor of the Proteasome Subunit Rpn11.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 50 | 5.82 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4104719 | — | — | 1 | 6.70 |
| CHEMBL4100384 | — | — | 1 | 6.52 |
| CHEMBL4073553 | — | — | 1 | 6.41 |
| CHEMBL4070821 | — | — | 1 | 6.40 |
| CHEMBL4093962 | — | — | 1 | 6.30 |
| CHEMBL4069023 | — | — | 1 | 6.10 |
| CHEMBL4088568 | — | — | 1 | 6.10 |
| CHEMBL4105598 | — | — | 1 | 6.10 |
| CHEMBL4060337 | — | — | 1 | 6.05 |
| CHEMBL4095913 | — | — | 1 | 6.05 |
| CHEMBL4093473 | — | — | 1 | 6.05 |
| CHEMBL4101230 | — | — | 1 | 6.05 |
| CHEMBL4077883 | — | — | 1 | 6.00 |
| CHEMBL4087722 | — | — | 1 | 6.00 |
| CHEMBL4078891 | — | — | 1 | 6.00 |
| CHEMBL4093484 | — | — | 1 | 5.96 |
| CHEMBL4095417 | — | — | 1 | 5.96 |
| CHEMBL4099434 | — | — | 1 | 5.92 |
| CHEMBL4065865 | — | — | 1 | 5.89 |
| CHEMBL4103171 | — | — | 1 | 5.80 |
| CHEMBL4100994 | — | — | 1 | 5.80 |
| CHEMBL4097864 | — | — | 1 | 5.66 |
| CHEMBL4076575 | — | — | 1 | 5.60 |
| CHEMBL4084782 | — | — | 1 | 5.60 |
| CHEMBL4065318 | — | — | 1 | 5.58 |
| CHEMBL4083926 | — | — | 1 | 5.50 |
| CHEMBL4062208 | — | — | 1 | 5.40 |
| CHEMBL4091693 | — | — | 1 | 5.34 |
| CHEMBL4063134 | — | — | 1 | 5.24 |
| CHEMBL4059915 | — | — | 1 | 5.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4104719 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL4100384 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL4073553 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL4070821 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL4093962 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL4069023 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL4088568 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL4105598 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL4060337 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL4095913 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL4093473 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL4101230 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL4078891 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4087722 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4077883 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4093484 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL4095417 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL4099434 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL4065865 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL4103171 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL4100994 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL4097864 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL4076575 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL4084782 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL4065318 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL4083926 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL4062208 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL4091693 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL4063134 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL4059915 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL4069573 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL4085174 | — | IC50 | = | 82000.0 | nM | 4.09 |
| CHEMBL4083010 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4085742 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4075311 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4076981 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL99932 | 8-AMINOQUINOLINE | IC50 | > | 100000.0 | nM | - |
| CHEMBL310555 | OXYQUINOLINE | IC50 | > | 100000.0 | nM | - |
| CHEMBL1702610 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4094874 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4074496 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4068027 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4086748 | — | IC50 | > | 2000.0 | nM | - |
| CHEMBL4080490 | — | IC50 | < | 200.0 | nM | - |
| CHEMBL4080694 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4091004 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL4070030 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL4103114 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4096289 | — | IC50 | < | 200.0 | nM | - |
| CHEMBL4079842 | — | IC50 | > | 100000.0 | nM | - |