Compound Detail
CHEMBL4069573
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Basic Information
| ChEMBL ID | CHEMBL4069573 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | SGHZZKBRDXCNBN-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
162.2
MW (Da)
1.92
ALogP
3
HBA
1
HBD
25.8
PSA (Ų)
0.60
QED
0
Ro5 Violations
0
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 4.82
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| 26S proteasome non-ATPase regulatory subunit 14 CHEMBL2007629 | IC50 | 4.82 | 4.82 | 15000.0 | 1 |
| Unchecked CHEMBL612545 | IC50 | 4.82 | 4.82 | 15000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| 26S proteasome non-ATPase regulatory subunit 14 | IC50 | = | 15000.0 | nM | 4.82 | Inhibition of 26S proteasome regulatory subunit RPN11 deubiquitinating activity ... | 28191850 |
| Unchecked | IC50 | = | 15000.0 | nM | 4.82 | Biochemical Assay: In brief, this Rpn11 bioassay employs a fluorescent polarizat... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 28191850 | 10.1021/acs.jmedchem.6b01379 | 26S proteasome non-ATPase regulatory subunit 14 | 1 |
Data from ChEMBL 36 via Core Engine