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Assay Detail

CHEMBL4049705

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Functional
Antiproliferative activity against human HCT116 cells after 72 hrs by Cell Titer-Glo assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HCT-116
Confidence 1 — Organism
Curated By Autocuration

Target

HCT-116 (CHEMBL394)
Type CELL-LINE
Organism Homo sapiens

Publication

Discovery of an Inhibitor of the Proteasome Subunit Rpn11.
Perez C, Li J, Parlati F, Rouffet M, Ma Y, Mackinnon AL, Chou TF, Deshaies RJ, Cohen SM.
J Med Chem (2017) 60 : 1343 -1361
PubMed 28191850 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 11 5.55 5.80

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4076575 1 5.80
CHEMBL4101230 1 5.68
CHEMBL4100994 1 5.58
CHEMBL4084782 1 5.47
CHEMBL310555 OXYQUINOLINE -1.0 1 5.22
CHEMBL4094874 1 -
CHEMBL1702610 1 -
CHEMBL4076981 1 -
CHEMBL4075311 1 -
CHEMBL4083010 1 -
CHEMBL4063134 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4076575 IC50 = 1600.0 nM 5.80
CHEMBL4101230 IC50 = 2100.0 nM 5.68
CHEMBL4100994 IC50 = 2600.0 nM 5.58
CHEMBL4084782 IC50 = 3400.0 nM 5.47
CHEMBL310555 OXYQUINOLINE IC50 = 6000.0 nM 5.22
CHEMBL4094874 IC50 > 100000.0 nM -
CHEMBL1702610 IC50 > 100000.0 nM -
CHEMBL4076981 IC50 > 100000.0 nM -
CHEMBL4075311 IC50 > 100000.0 nM -
CHEMBL4083010 IC50 > 50000.0 nM -
CHEMBL4063134 IC50 > 10000.0 nM -