Assay Detail
Binding
CHEMBL4049706
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of CSN5 (unknown origin) using SCFskp2-Nedd8OG as substrate after 1 hr by fluorescence polarization assay
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
COP9 signalosome complex subunit 5 (CHEMBL4105809) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of an Inhibitor of the Proteasome Subunit Rpn11.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 33 | 5.04 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4088568 | — | — | 1 | 6.52 |
| CHEMBL4096289 | — | — | 1 | 6.30 |
| CHEMBL4101230 | — | — | 1 | 5.80 |
| CHEMBL4084782 | — | — | 1 | 5.54 |
| CHEMBL4100384 | — | — | 1 | 5.40 |
| CHEMBL4060337 | — | — | 1 | 5.16 |
| CHEMBL4104719 | — | — | 1 | 5.16 |
| CHEMBL4099434 | — | — | 1 | 5.16 |
| CHEMBL4100994 | — | — | 1 | 5.15 |
| CHEMBL4076575 | — | — | 1 | 4.99 |
| CHEMBL4095417 | — | — | 1 | 4.96 |
| CHEMBL4065318 | — | — | 1 | 4.82 |
| CHEMBL4078891 | — | — | 1 | 4.82 |
| CHEMBL4105598 | — | — | 1 | 4.80 |
| CHEMBL4080490 | — | — | 1 | 4.75 |
| CHEMBL4070821 | — | — | 1 | 4.70 |
| CHEMBL4093962 | — | — | 1 | 4.62 |
| CHEMBL4063134 | — | — | 1 | 4.60 |
| CHEMBL4073553 | — | — | 1 | 4.52 |
| CHEMBL4103114 | — | — | 1 | 4.46 |
| CHEMBL4091693 | — | — | 1 | 4.39 |
| CHEMBL4103171 | — | — | 1 | 4.17 |
| CHEMBL4085174 | — | — | 1 | - |
| CHEMBL4059915 | — | — | 1 | - |
| CHEMBL4080694 | — | — | 1 | - |
| CHEMBL4091004 | — | — | 1 | - |
| CHEMBL4070030 | — | — | 1 | - |
| CHEMBL4069023 | — | — | 1 | - |
| CHEMBL4083926 | — | — | 1 | - |
| CHEMBL4062208 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4088568 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL4096289 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL4101230 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL4084782 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL4100384 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL4060337 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL4104719 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL4099434 | — | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL4100994 | — | IC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL4076575 | — | IC50 | = | 10300.0 | nM | 4.99 |
| CHEMBL4095417 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL4065318 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL4078891 | — | IC50 | = | 15300.0 | nM | 4.82 |
| CHEMBL4105598 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL4080490 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL4070821 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL4093962 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL4063134 | — | IC50 | = | 25100.0 | nM | 4.60 |
| CHEMBL4073553 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL4103114 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL4091693 | — | IC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL4103171 | — | IC50 | = | 68000.0 | nM | 4.17 |
| CHEMBL4085174 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4059915 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4080694 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4091004 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4070030 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4069023 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4083926 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4062208 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4086748 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4095913 | — | IC50 | < | 500.0 | nM | - |
| CHEMBL4083010 | — | IC50 | > | 100000.0 | nM | - |