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Assay Detail

CHEMBL4049960

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human erythrocyte AChE using acetylthiocholine chloride as substrate pretreated for 15 mins followed by substrate addition measured for 2 mins by DTNB reagent based spectrophotometric method
ChEMBL ↗
43
Total Activities
43
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Acetylcholinesterase (CHEMBL220) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Design, synthesis and evaluation of 2-arylethenyl-N-methylquinolinium derivatives as effective multifunctional agents for Alzheimer's disease treatment.
Xia CL, Wang N, Guo QL, Liu ZQ, Wu JQ, Huang SL, Ou TM, Tan JH, Wang HG, Li D, Huang ZS.
Eur J Med Chem (2017) 130 : 139 -153
PubMed 28242549 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 43 5.91 7.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL502 DONEPEZIL 4.0 1 7.52
CHEMBL95 TACRINE 4.0 1 6.52
CHEMBL3425895 — — 1 6.52
CHEMBL4066392 — — 1 6.40
CHEMBL1242180 — — 1 6.30
CHEMBL4080358 — — 1 6.22
CHEMBL3425894 — — 1 6.16
CHEMBL4097284 — — 1 6.16
CHEMBL4096862 — — 1 6.00
CHEMBL4070093 — — 1 5.85
CHEMBL4061433 — — 1 5.82
CHEMBL3425891 — — 1 5.80
CHEMBL3425881 — — 1 5.77
CHEMBL1303143 — — 1 5.75
CHEMBL3425892 — — 1 5.72
CHEMBL4093946 — — 1 5.68
CHEMBL4095051 — — 1 5.64
CHEMBL3425893 — — 1 5.62
CHEMBL597863 — — 1 5.62
CHEMBL4093514 — — 1 5.60
CHEMBL3425890 — — 1 5.55
CHEMBL4086383 — — 1 5.38
CHEMBL3425889 — — 1 5.37
CHEMBL4104589 — — 1 5.36
CHEMBL4067639 — — 1 5.36
CHEMBL3425908 — — 1 -
CHEMBL165 RESVERATROL 3.0 1 -
CHEMBL140 CURCUMIN 3.0 1 -
CHEMBL4086807 — — 1 -
CHEMBL4065374 — — 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL502 DONEPEZIL IC50 = 30.0 nM 7.52
CHEMBL95 TACRINE IC50 = 300.0 nM 6.52
CHEMBL3425895 — IC50 = 300.0 nM 6.52
CHEMBL4066392 — IC50 = 400.0 nM 6.40
CHEMBL1242180 — IC50 = 500.0 nM 6.30
CHEMBL4080358 — IC50 = 600.0 nM 6.22
CHEMBL3425894 — IC50 = 700.0 nM 6.16
CHEMBL4097284 — IC50 = 700.0 nM 6.16
CHEMBL4096862 — IC50 = 1000.0 nM 6.00
CHEMBL4070093 — IC50 = 1400.0 nM 5.85
CHEMBL4061433 — IC50 = 1500.0 nM 5.82
CHEMBL3425891 — IC50 = 1600.0 nM 5.80
CHEMBL3425881 — IC50 = 1700.0 nM 5.77
CHEMBL1303143 — IC50 = 1800.0 nM 5.75
CHEMBL3425892 — IC50 = 1900.0 nM 5.72
CHEMBL4093946 — IC50 = 2100.0 nM 5.68
CHEMBL4095051 — IC50 = 2300.0 nM 5.64
CHEMBL3425893 — IC50 = 2400.0 nM 5.62
CHEMBL597863 — IC50 = 2400.0 nM 5.62
CHEMBL4093514 — IC50 = 2500.0 nM 5.60
CHEMBL3425890 — IC50 = 2800.0 nM 5.55
CHEMBL4086383 — IC50 = 4200.0 nM 5.38
CHEMBL3425889 — IC50 = 4300.0 nM 5.37
CHEMBL4104589 — IC50 = 4400.0 nM 5.36
CHEMBL4067639 — IC50 = 4400.0 nM 5.36
CHEMBL3425885 — IC50 > 5000.0 nM -
CHEMBL4060972 — IC50 > 5000.0 nM -
CHEMBL4089155 — IC50 > 5000.0 nM -
CHEMBL4099308 — IC50 > 5000.0 nM -
CHEMBL4086152 — IC50 > 5000.0 nM -
CHEMBL4065910 — IC50 > 5000.0 nM -
CHEMBL4064920 — IC50 > 5000.0 nM -
CHEMBL4078528 — IC50 > 5000.0 nM -
CHEMBL4102810 — IC50 > 5000.0 nM -
CHEMBL4105221 — IC50 > 5000.0 nM -
CHEMBL4087364 — IC50 > 5000.0 nM -
CHEMBL4072484 — IC50 > 5000.0 nM -
CHEMBL4099404 — IC50 > 5000.0 nM -
CHEMBL4065374 — IC50 > 5000.0 nM -
CHEMBL4086807 — IC50 > 5000.0 nM -
CHEMBL140 CURCUMIN IC50 > 5000.0 nM -
CHEMBL165 RESVERATROL IC50 > 5000.0 nM -
CHEMBL3425908 — IC50 > 5000.0 nM -