Assay Detail
Functional
CHEMBL4050076
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Antiproliferative activity human A375 cells after 72 hrs by cell titer-glo luminescence assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A-375 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and evaluation of derivatives based on pyrimidine scaffold as potent Pan-Raf inhibitors to overcome resistance.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.57 | 6.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4080362 | — | — | 1 | 6.17 |
| CHEMBL1229517 | VEMURAFENIB | 4.0 | 1 | 6.16 |
| CHEMBL4075036 | — | — | 1 | 5.99 |
| CHEMBL4101717 | — | — | 1 | 5.74 |
| CHEMBL4085294 | — | — | 1 | 5.64 |
| CHEMBL4066939 | — | — | 1 | 5.57 |
| CHEMBL4063679 | — | — | 1 | 5.55 |
| CHEMBL4060531 | — | — | 1 | 5.44 |
| CHEMBL4082425 | — | — | 1 | 5.43 |
| CHEMBL4104590 | — | — | 1 | 5.33 |
| CHEMBL4060057 | — | — | 1 | 4.97 |
| CHEMBL1336 | SORAFENIB | 4.0 | 1 | 4.87 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4080362 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL1229517 | VEMURAFENIB | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL4075036 | — | IC50 | = | 1020.0 | nM | 5.99 |
| CHEMBL4101717 | — | IC50 | = | 1810.0 | nM | 5.74 |
| CHEMBL4085294 | — | IC50 | = | 2270.0 | nM | 5.64 |
| CHEMBL4066939 | — | IC50 | = | 2680.0 | nM | 5.57 |
| CHEMBL4063679 | — | IC50 | = | 2830.0 | nM | 5.55 |
| CHEMBL4060531 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL4082425 | — | IC50 | = | 3740.0 | nM | 5.43 |
| CHEMBL4104590 | — | IC50 | = | 4730.0 | nM | 5.33 |
| CHEMBL4060057 | — | IC50 | = | 10600.0 | nM | 4.97 |
| CHEMBL1336 | SORAFENIB | IC50 | = | 13640.0 | nM | 4.87 |