Assay Detail
Functional
CHEMBL4050171
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Antiproliferative activity against human BT549 cells assessed as reduction in cell viability after 5 to 7 days by CellTiter 96 aqueous solution assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | BT-549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel pyrrolopyrimidines as Mps1/TTK kinase inhibitors for breast cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.12 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4076767 | — | — | 1 | 7.22 |
| CHEMBL3330411 | — | — | 1 | 6.09 |
| CHEMBL4091309 | — | — | 1 | 5.89 |
| CHEMBL1235786 | — | — | 1 | 5.76 |
| CHEMBL4061742 | — | — | 1 | 5.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4076767 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL3330411 | — | IC50 | = | 810.0 | nM | 6.09 |
| CHEMBL4091309 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL1235786 | — | IC50 | = | 1730.0 | nM | 5.76 |
| CHEMBL4061742 | — | IC50 | = | 2190.0 | nM | 5.66 |