Assay Detail
Functional
CHEMBL4050180
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human MDA-MB-453 cells assessed as reduction in cell viability after 5 to 7 days by CellTiter 96 aqueous solution assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-453 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel pyrrolopyrimidines as Mps1/TTK kinase inhibitors for breast cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.28 | 6.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4076767 | — | — | 1 | 6.46 |
| CHEMBL3330411 | — | — | 1 | 6.09 |
| CHEMBL4061742 | — | — | 1 | - |
| CHEMBL4091309 | — | — | 1 | - |
| CHEMBL1235786 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4076767 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL3330411 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL4061742 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4091309 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1235786 | — | IC50 | > | 10000.0 | nM | - |