Assay Detail
Binding
CHEMBL4050596
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human PACE4 expressed in drosophila S2 cells using pyrGlu-Arg-Thr-Lys-Arg-7-amido-4-methylcoumarin as substrate after 60 mins by spectrofluorometry method
75
Total Activities
75
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Proprotein convertase subtilisin/kexin type 6 (CHEMBL2951) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Positional Scanning Identifies the Molecular Determinants of a High Affinity Multi-Leucine Inhibitor for Furin and PACE4.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 75 | 8.30 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4089819 | — | — | 1 | 9.70 |
| CHEMBL4065072 | — | — | 1 | 9.52 |
| CHEMBL4084457 | — | — | 1 | 9.40 |
| CHEMBL4091099 | — | — | 1 | 9.40 |
| CHEMBL4100996 | — | — | 1 | 9.30 |
| CHEMBL4104777 | — | — | 1 | 9.22 |
| CHEMBL4070237 | — | — | 1 | 9.05 |
| CHEMBL4064275 | — | — | 1 | 9.00 |
| CHEMBL4083310 | — | — | 1 | 9.00 |
| CHEMBL4073661 | — | — | 1 | 8.89 |
| CHEMBL4094478 | — | — | 1 | 8.82 |
| CHEMBL4099961 | — | — | 1 | 8.77 |
| CHEMBL4097940 | — | — | 1 | 8.74 |
| CHEMBL4093570 | — | — | 1 | 8.70 |
| CHEMBL4063327 | — | — | 1 | 8.70 |
| CHEMBL4096348 | — | — | 1 | 8.70 |
| CHEMBL4101342 | — | — | 1 | 8.70 |
| CHEMBL4103443 | — | — | 1 | 8.70 |
| CHEMBL4087970 | — | — | 1 | 8.70 |
| CHEMBL4085824 | — | — | 1 | 8.70 |
| CHEMBL4075692 | — | — | 1 | 8.68 |
| CHEMBL4072949 | — | — | 1 | 8.66 |
| CHEMBL4065627 | — | — | 1 | 8.60 |
| CHEMBL4084913 | — | — | 1 | 8.55 |
| CHEMBL4059801 | — | — | 1 | 8.55 |
| CHEMBL4067772 | — | — | 1 | 8.52 |
| CHEMBL4063219 | — | — | 1 | 8.52 |
| CHEMBL4089913 | — | — | 1 | 8.52 |
| CHEMBL4080551 | — | — | 1 | 8.52 |
| CHEMBL4093266 | — | — | 1 | 8.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4089819 | — | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL4065072 | — | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL4084457 | — | Ki | = | 0.4 | nM | 9.40 |
| CHEMBL4091099 | — | Ki | = | 0.4 | nM | 9.40 |
| CHEMBL4100996 | — | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL4104777 | — | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL4070237 | — | Ki | = | 0.9 | nM | 9.05 |
| CHEMBL4064275 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL4083310 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL4073661 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL4094478 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL4099961 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL4097940 | — | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL4087970 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL4063327 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL4096348 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL4101342 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL4103443 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL4093570 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL4085824 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL4075692 | — | Ki | = | 2.1 | nM | 8.68 |
| CHEMBL4072949 | — | Ki | = | 2.2 | nM | 8.66 |
| CHEMBL4065627 | — | Ki | = | 2.5 | nM | 8.60 |
| CHEMBL4084913 | — | Ki | = | 2.8 | nM | 8.55 |
| CHEMBL4059801 | — | Ki | = | 2.8 | nM | 8.55 |
| CHEMBL4067772 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL4093266 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL4080551 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL4063219 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL4089913 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL4076965 | — | Ki | = | 3.7 | nM | 8.43 |
| CHEMBL4063459 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL4066994 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL4060537 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL4101304 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL4092088 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL4077533 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL4097058 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL4091172 | — | Ki | = | 4.1 | nM | 8.39 |
| CHEMBL4066673 | — | Ki | = | 4.8 | nM | 8.32 |
| CHEMBL4103458 | — | Ki | = | 4.9 | nM | 8.31 |
| CHEMBL4074250 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL4061196 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL4094278 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL4061737 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL4069865 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL4068820 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL4086512 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL4081957 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL4099504 | — | Ki | = | 6.2 | nM | 8.21 |