Compound Detail
CHEMBL4073661
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CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)NCc1ccc(C(=N)N)cc1)C(C)C
Basic Information
| ChEMBL ID | CHEMBL4073661 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | CITXKWUJEIHJAG-FVMQRRFMSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
1051.3
MW (Da)
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 2 meas. best 8.89
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Proprotein convertase subtilisin/kexin type 6 CHEMBL2951 | Ki | 8.89 | 8.89 | 1.3 | 1 |
| Furin CHEMBL2611 | Ki | 8.74 | 8.74 | 1.8 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Proprotein convertase subtilisin/kexin type 6 | Ki | = | 1.3 | nM | 8.89 | Inhibition of recombinant human PACE4 expressed in drosophila S2 cells using pyr... | 28287731 |
| Furin | Ki | = | 1.8 | nM | 8.74 | Inhibition of recombinant human furin expressed in drosophila S2 cells using pyr... | 28287731 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 28287731 | 10.1021/acs.jmedchem.6b01499 | Proprotein convertase subtilisin/kexin type 6 | 1 |
| 28287731 | 10.1021/acs.jmedchem.6b01499 | Furin | 1 |
| 28287731 | 10.1021/acs.jmedchem.6b01499 | Unchecked | 1 |
| 28287731 | 10.1021/acs.jmedchem.6b01499 | DU-145 | 1 |
Data from ChEMBL 36 via Core Engine