Assay Detail
Functional
CHEMBL4050605
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human K562/A02 cells overexpressing P-gp after 48 hrs by MTT assay
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | K562/A02 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Exploration of 2-((Pyridin-4-ylmethyl)amino)nicotinamide Derivatives as Potent Reversal Agents against P-Glycoprotein-Mediated Multidrug Resistance.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 36 | 4.35 | 4.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3186534 | RIVOCERANIB | 3.0 | 1 | 4.70 |
| CHEMBL248976 | — | — | 1 | 4.55 |
| CHEMBL4066132 | — | — | 1 | 4.55 |
| CHEMBL248978 | — | — | 1 | 4.54 |
| CHEMBL6966 | VERAPAMIL | 4.0 | 1 | 4.50 |
| CHEMBL359744 | DOXORUBICIN HYDROCHLORIDE | 4.0 | 1 | 4.27 |
| CHEMBL4097071 | — | — | 1 | 4.13 |
| CHEMBL4077203 | — | — | 1 | 4.08 |
| CHEMBL4100370 | — | — | 1 | 4.07 |
| CHEMBL4093402 | — | — | 1 | 4.07 |
| CHEMBL4083907 | — | — | 1 | - |
| CHEMBL4073532 | — | — | 1 | - |
| CHEMBL4101424 | — | — | 1 | - |
| CHEMBL4104472 | — | — | 1 | - |
| CHEMBL4074739 | — | — | 1 | - |
| CHEMBL4066822 | — | — | 1 | - |
| CHEMBL4094326 | — | — | 1 | - |
| CHEMBL4077805 | — | — | 1 | - |
| CHEMBL4102066 | — | — | 1 | - |
| CHEMBL4085660 | — | — | 1 | - |
| CHEMBL4062182 | — | — | 1 | - |
| CHEMBL4091675 | — | — | 1 | - |
| CHEMBL4070798 | — | — | 1 | - |
| CHEMBL4099415 | — | — | 1 | - |
| CHEMBL400102 | — | — | 1 | - |
| CHEMBL4061101 | — | — | 1 | - |
| CHEMBL4089265 | — | — | 1 | - |
| CHEMBL4089366 | — | — | 1 | - |
| CHEMBL4085007 | — | — | 1 | - |
| CHEMBL4061215 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3186534 | RIVOCERANIB | IC50 | = | 19760.0 | nM | 4.70 |
| CHEMBL248976 | — | IC50 | = | 27930.0 | nM | 4.55 |
| CHEMBL4066132 | — | IC50 | = | 27930.0 | nM | 4.55 |
| CHEMBL248978 | — | IC50 | = | 28690.0 | nM | 4.54 |
| CHEMBL6966 | VERAPAMIL | IC50 | = | 31280.0 | nM | 4.50 |
| CHEMBL359744 | DOXORUBICIN HYDROCHLORIDE | IC50 | = | 53950.0 | nM | 4.27 |
| CHEMBL4097071 | — | IC50 | = | 74890.0 | nM | 4.13 |
| CHEMBL4077203 | — | IC50 | = | 82150.0 | nM | 4.08 |
| CHEMBL4100370 | — | IC50 | = | 85730.0 | nM | 4.07 |
| CHEMBL4093402 | — | IC50 | = | 86030.0 | nM | 4.07 |
| CHEMBL4104472 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4093705 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4074739 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4066822 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4094326 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4077805 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4102066 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4085660 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4064088 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4098031 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4070940 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4068093 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4103885 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4101424 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4073532 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4083907 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4062182 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4091675 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4070798 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4099415 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL400102 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4061101 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4089265 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4089366 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4085007 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4061215 | — | IC50 | > | 100000.0 | nM | - |