Assay Detail
Functional
CHEMBL4050864
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Antiproliferative activity against human Raji cells after 72 hrs by MTT assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Raji |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design and synthesis of novel 6-aryl substituted 4-anilinequinazoline derivatives as potential PI3Kδ inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.68 | 9.02 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4087607 | — | — | 1 | 9.02 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 9.01 |
| CHEMBL2216870 | IDELALISIB | 4.0 | 1 | 8.00 |
| CHEMBL4078784 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4087607 | — | IC50 | = | 0.95 | nM | 9.02 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 0.97 | nM | 9.01 |
| CHEMBL2216870 | IDELALISIB | IC50 | = | 9.95 | nM | 8.00 |
| CHEMBL4078784 | — | IC50 | > | 10.0 | nM | - |