Assay Detail
Binding
CHEMBL4051035
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Agonist activity at recombinant human beta3 adrenergic receptor expressed in CHO cells assessed as accumulation of cyclic AMP after 30 mins
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of Novel Indazole Derivatives as Orally Available β3-Adrenergic Receptor Agonists Lacking Off-Target-Based Cardiovascular Side Effects.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 14 | 7.66 | 8.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL188622 | — | — | 1 | 8.77 |
| CHEMBL4089669 | — | — | 1 | 8.41 |
| CHEMBL4104183 | — | — | 1 | 8.19 |
| CHEMBL3601305 | — | — | 1 | 7.89 |
| CHEMBL3601204 | — | — | 1 | 7.85 |
| CHEMBL4073098 | — | — | 1 | 7.75 |
| CHEMBL4067502 | — | — | 1 | 7.75 |
| CHEMBL3601200 | — | — | 1 | 7.68 |
| CHEMBL4080868 | — | — | 1 | 7.37 |
| CHEMBL3601307 | — | — | 1 | 7.18 |
| CHEMBL4105097 | — | — | 1 | 7.16 |
| CHEMBL434 | ISOPROTERENOL | 4.0 | 1 | 7.07 |
| CHEMBL4088750 | — | — | 1 | 6.51 |
| CHEMBL1437 | NOREPINEPHRINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL188622 | — | EC50 | = | 1.7 | nM | 8.77 |
| CHEMBL4089669 | — | EC50 | = | 3.9 | nM | 8.41 |
| CHEMBL4104183 | — | EC50 | = | 6.5 | nM | 8.19 |
| CHEMBL3601305 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL3601204 | — | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4073098 | — | EC50 | = | 18.0 | nM | 7.75 |
| CHEMBL4067502 | — | EC50 | = | 18.0 | nM | 7.75 |
| CHEMBL3601200 | — | EC50 | = | 21.0 | nM | 7.68 |
| CHEMBL4080868 | — | EC50 | = | 43.0 | nM | 7.37 |
| CHEMBL3601307 | — | EC50 | = | 66.0 | nM | 7.18 |
| CHEMBL4105097 | — | EC50 | = | 70.0 | nM | 7.16 |
| CHEMBL434 | ISOPROTERENOL | EC50 | = | 86.0 | nM | 7.07 |
| CHEMBL4088750 | — | EC50 | = | 309.0 | nM | 6.51 |
| CHEMBL1437 | NOREPINEPHRINE | EC50 | - | — | - |