Assay Detail
Binding
CHEMBL4051395
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Binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 2 hrs by liquid scintillation counting assay
4
Total Activities
2
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Radiolabeled Dibenzodiazepinone-Type Antagonists Give Evidence of Dualsteric Binding at the M2 Muscarinic Acetylcholine Receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Bmax | 2 | - | - |
| Kd | 2 | 9.09 | 9.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4089543 | — | — | 2 | 9.66 |
| CHEMBL4068393 | — | — | 2 | 8.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4089543 | — | Kd | = | 0.22 | nM | 9.66 |
| CHEMBL4068393 | — | Kd | = | 3.0 | nM | 8.52 |
| CHEMBL4068393 | — | Bmax | = | 4900.0 | disintegrations/minute | - |
| CHEMBL4089543 | — | Bmax | = | 620.0 | disintegrations/minute | - |