Assay Detail
Binding
CHEMBL4051802
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Inhibition of human placental microsomal STS assessed as formation of E1 preincubated for 30 mins followed by addition of E1S as substrate measured after 20 mins by ELISA
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
First Dual Inhibitors of Steroid Sulfatase (STS) and 17β-Hydroxysteroid Dehydrogenase Type 1 (17β-HSD1): Designed Multiple Ligands as Novel Potential Therapeutics for Estrogen-Dependent Diseases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 7.18 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL286738 | IROSUSTAT | 2.0 | 1 | 7.82 |
| CHEMBL4091943 | — | — | 1 | 7.71 |
| CHEMBL4064200 | — | — | 1 | 7.71 |
| CHEMBL4084183 | — | — | 1 | 7.46 |
| CHEMBL4102153 | — | — | 1 | 7.09 |
| CHEMBL4099681 | — | — | 1 | 6.98 |
| CHEMBL4066635 | — | — | 1 | 6.91 |
| CHEMBL4071245 | — | — | 1 | 6.84 |
| CHEMBL4083248 | — | — | 1 | 6.66 |
| CHEMBL4072794 | — | — | 1 | 6.61 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL286738 | IROSUSTAT | IC50 | = | 15.1 | nM | 7.82 |
| CHEMBL4091943 | — | IC50 | = | 19.5 | nM | 7.71 |
| CHEMBL4064200 | — | IC50 | = | 19.4 | nM | 7.71 |
| CHEMBL4084183 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL4102153 | — | IC50 | = | 81.8 | nM | 7.09 |
| CHEMBL4099681 | — | IC50 | = | 105.5 | nM | 6.98 |
| CHEMBL4066635 | — | IC50 | = | 123.4 | nM | 6.91 |
| CHEMBL4071245 | — | IC50 | = | 143.1 | nM | 6.84 |
| CHEMBL4083248 | — | IC50 | = | 220.8 | nM | 6.66 |
| CHEMBL4072794 | — | IC50 | = | 244.5 | nM | 6.61 |