Assay Detail
Binding
CHEMBL4051995
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Influenza A virus A/Udorn/72 wild-type M2 proton channel expressed in Xenopus laevis oocytes at pH 5.5 after 2 mins at -20 mV holding potential by two-electrode voltage clamp assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Influenza A virus (A/udorn/1972(H3N2)) |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Matrix protein 2 (CHEMBL2052) ↗| Type | SINGLE PROTEIN |
| Organism | Influenza A virus (A/Udorn/307/1972(H3N2)) |
Publication
Slow but Steady Wins the Race: Dissimilarities among New Dual Inhibitors of the Wild-Type and the V27A Mutant M2 Channels of Influenza A Virus.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.20 | 5.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4074389 | — | — | 1 | 5.72 |
| CHEMBL4104405 | — | — | 1 | 5.39 |
| CHEMBL4096027 | — | — | 1 | 5.38 |
| CHEMBL4061974 | — | — | 1 | 5.17 |
| CHEMBL4094873 | — | — | 1 | 4.34 |
| CHEMBL294443 | — | — | 1 | - |
| CHEMBL4059787 | — | — | 1 | - |
| CHEMBL4064734 | — | — | 1 | - |
| CHEMBL4092431 | — | — | 1 | - |
| CHEMBL4073320 | — | — | 1 | - |
| CHEMBL4100170 | — | — | 1 | - |
| CHEMBL4070224 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4074389 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL4104405 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL4096027 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL4061974 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL4094873 | — | IC50 | = | 45300.0 | nM | 4.34 |
| CHEMBL294443 | — | IC50 | - | — | - | |
| CHEMBL4059787 | — | IC50 | - | — | - | |
| CHEMBL4064734 | — | IC50 | - | — | - | |
| CHEMBL4092431 | — | IC50 | - | — | - | |
| CHEMBL4073320 | — | IC50 | - | — | - | |
| CHEMBL4100170 | — | IC50 | - | — | - | |
| CHEMBL4070224 | — | IC50 | - | — | - |