Assay Detail
Binding
CHEMBL4052001
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Inhibition of Influenza A virus A/Udorn/72 amantadine-resistant M2 proton channel V27A mutant expressed in Xenopus laevis oocytes at pH 5.5 after 2 mins at -20 mV holding potential by two-electrode voltage clamp assay relative to control
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Influenza A virus (A/udorn/1972(H3N2)) |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Matrix protein 2 (CHEMBL2052) ↗| Type | SINGLE PROTEIN |
| Organism | Influenza A virus (A/Udorn/307/1972(H3N2)) |
Publication
Slow but Steady Wins the Race: Dissimilarities among New Dual Inhibitors of the Wild-Type and the V27A Mutant M2 Channels of Influenza A Virus.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 4.69 | 5.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4104405 | — | — | 1 | 5.44 |
| CHEMBL4074389 | — | — | 1 | 4.79 |
| CHEMBL4096027 | — | — | 1 | 4.66 |
| CHEMBL4061974 | — | — | 1 | 4.34 |
| CHEMBL4094873 | — | — | 1 | 4.22 |
| CHEMBL294443 | — | — | 1 | - |
| CHEMBL4059787 | — | — | 1 | - |
| CHEMBL4064734 | — | — | 1 | - |
| CHEMBL4092431 | — | — | 1 | - |
| CHEMBL4073320 | — | — | 1 | - |
| CHEMBL4100170 | — | — | 1 | - |
| CHEMBL4070224 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4104405 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL4074389 | — | IC50 | = | 16200.0 | nM | 4.79 |
| CHEMBL4096027 | — | IC50 | = | 21700.0 | nM | 4.66 |
| CHEMBL4061974 | — | IC50 | = | 46000.0 | nM | 4.34 |
| CHEMBL4094873 | — | IC50 | = | 60600.0 | nM | 4.22 |
| CHEMBL294443 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL4059787 | — | IC50 | - | — | - | |
| CHEMBL4064734 | — | IC50 | - | — | - | |
| CHEMBL4092431 | — | IC50 | - | — | - | |
| CHEMBL4073320 | — | IC50 | - | — | - | |
| CHEMBL4100170 | — | IC50 | - | — | - | |
| CHEMBL4070224 | — | IC50 | - | — | - |