Assay Detail
Functional
CHEMBL4052035
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against indinavir-resistant HIV1 NL4-3 harboring protease L10F/L24I/M46I/I54V/L63P/A71V/G73S/V82T mutant infected in human MT4 cells assessed as reduction in p24 Gag protein production after 7 days by chemiluminescent enzyme immunoassay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Design and Development of Highly Potent HIV-1 Protease Inhibitors with a Crown-Like Oxotricyclic Core as the P2-Ligand To Combat Multidrug-Resistant HIV Variants.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.11 | 10.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4098771 | — | — | 1 | 10.92 |
| CHEMBL1323 | DARUNAVIR | 4.0 | 1 | 7.52 |
| CHEMBL1163 | ATAZANAVIR | 4.0 | 1 | 7.21 |
| CHEMBL729 | LOPINAVIR | 4.0 | 1 | 6.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4098771 | — | IC50 | = | 0.012 | nM | 10.92 |
| CHEMBL1323 | DARUNAVIR | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL1163 | ATAZANAVIR | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL729 | LOPINAVIR | IC50 | = | 170.0 | nM | 6.77 |