Assay Detail
Binding
CHEMBL4052121
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Inhibition of PIM3 (unknown origin) using 5FAM-ARKRRRHPSGPPTA as substrate after 90 mins in presence of ATP by caliper microfluidic mobility shift assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase pim-3 (CHEMBL5407) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of 5-Azaindazole (GNE-955) as a Potent Pan-Pim Inhibitor with Optimized Bioavailability.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 17 | 9.45 | 10.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3634758 | — | — | 1 | 10.70 |
| CHEMBL3960554 | — | — | 1 | 10.70 |
| CHEMBL4076913 | — | — | 1 | 10.70 |
| CHEMBL3956349 | — | — | 1 | 10.70 |
| CHEMBL4091687 | — | — | 1 | 10.52 |
| CHEMBL3978766 | — | — | 1 | 10.40 |
| CHEMBL3956461 | — | — | 1 | 10.00 |
| CHEMBL4097308 | — | — | 1 | 9.70 |
| CHEMBL3915064 | — | — | 1 | 9.70 |
| CHEMBL4089586 | — | — | 1 | 9.40 |
| CHEMBL4061456 | — | — | 1 | 9.40 |
| CHEMBL4070117 | — | — | 1 | 9.10 |
| CHEMBL4081716 | — | — | 1 | 9.00 |
| CHEMBL4088342 | — | — | 1 | 7.64 |
| CHEMBL4060101 | — | — | 1 | 6.92 |
| CHEMBL4099731 | — | — | 1 | 6.57 |
| CHEMBL3914639 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3634758 | — | Ki | = | 0.02 | nM | 10.70 |
| CHEMBL3960554 | — | Ki | = | 0.02 | nM | 10.70 |
| CHEMBL4076913 | — | Ki | = | 0.02 | nM | 10.70 |
| CHEMBL3956349 | — | Ki | = | 0.02 | nM | 10.70 |
| CHEMBL4091687 | — | Ki | = | 0.03 | nM | 10.52 |
| CHEMBL3978766 | — | Ki | = | 0.04 | nM | 10.40 |
| CHEMBL3956461 | — | Ki | = | 0.1 | nM | 10.00 |
| CHEMBL4097308 | — | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL3915064 | — | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL4089586 | — | Ki | = | 0.4 | nM | 9.40 |
| CHEMBL4061456 | — | Ki | = | 0.4 | nM | 9.40 |
| CHEMBL4070117 | — | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL4081716 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL4088342 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL4060101 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL4099731 | — | Ki | = | 270.0 | nM | 6.57 |
| CHEMBL3914639 | — | Ki | = | 0.008 | nM | - |