Assay Detail
ADMET
CHEMBL4052361
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Inhibition of human COX-1 preincubated for 15 mins followed by fluorometric substrate/heme addition for 15 mins subsequently incubated with arachidonic acid for 2 mins by fluorescence analysis
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Pentafluorosulfanyl-Substituted Benzopyran Analogues As New Cyclooxygenase-2 Inhibitors with Excellent Pharmacokinetics and Efficacy in Blocking Inflammation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 7.28 | 7.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL26915 | SC-560 | — | 1 | 7.28 |
| CHEMBL4075294 | — | — | 1 | - |
| CHEMBL42485 | DUP-697 | — | 1 | - |
| CHEMBL118 | CELECOXIB | 4.0 | 1 | - |
| CHEMBL4098347 | — | — | 1 | - |
| CHEMBL4080317 | — | — | 1 | - |
| CHEMBL4090622 | — | — | 1 | - |
| CHEMBL4069602 | — | — | 1 | - |
| CHEMBL4088012 | — | — | 1 | - |
| CHEMBL4095906 | — | — | 1 | - |
| CHEMBL4084676 | — | — | 1 | - |
| CHEMBL4072067 | — | — | 1 | - |
| CHEMBL4081499 | — | — | 1 | - |
| CHEMBL4062140 | — | — | 1 | - |
| CHEMBL4074716 | — | — | 1 | - |
| CHEMBL4091547 | — | — | 1 | - |
| CHEMBL4068589 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL26915 | SC-560 | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL4075294 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL42485 | DUP-697 | IC50 | > | 10000.0 | nM | - |
| CHEMBL118 | CELECOXIB | IC50 | > | 10000.0 | nM | - |
| CHEMBL4098347 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4080317 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4090622 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4069602 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4088012 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4095906 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4084676 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4072067 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4081499 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4062140 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4074716 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4091547 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4068589 | — | IC50 | > | 10000.0 | nM | - |