Assay Detail
Functional
CHEMBL4052385
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV2 ROD harboring reverse transcriptase infected in human MT4 cells assessed as protection against virus induced cytotoxicity after 5 days by MTT assay
46
Total Activities
46
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 2 (CHEMBL380) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 2 |
Publication
Structure-Based Optimization of Thiophene[3,2-d]pyrimidine Derivatives as Potent HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors with Improved Potency against Resistance-Associated Variants.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 46 | 5.18 | 5.18 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4100811 | — | — | 1 | 5.18 |
| CHEMBL4067573 | — | — | 1 | - |
| CHEMBL4093101 | — | — | 1 | - |
| CHEMBL4074049 | — | — | 1 | - |
| CHEMBL4089717 | — | — | 1 | - |
| CHEMBL4061597 | — | — | 1 | - |
| CHEMBL4062672 | — | — | 1 | - |
| CHEMBL4089725 | — | — | 1 | - |
| CHEMBL4080133 | — | — | 1 | - |
| CHEMBL4059713 | — | — | 1 | - |
| CHEMBL4088003 | — | — | 1 | - |
| CHEMBL4082607 | — | — | 1 | - |
| CHEMBL4060732 | — | — | 1 | - |
| CHEMBL4090441 | — | — | 1 | - |
| CHEMBL4069411 | — | — | 1 | - |
| CHEMBL4094991 | — | — | 1 | - |
| CHEMBL4102745 | — | — | 1 | - |
| CHEMBL4094163 | — | — | 1 | - |
| CHEMBL4076005 | — | — | 1 | - |
| CHEMBL4086331 | — | — | 1 | - |
| CHEMBL4077355 | — | — | 1 | - |
| CHEMBL4094095 | — | — | 1 | - |
| CHEMBL4083835 | — | — | 1 | - |
| CHEMBL4101836 | — | — | 1 | - |
| CHEMBL4096564 | — | — | 1 | - |
| CHEMBL4078540 | — | — | 1 | - |
| CHEMBL4075243 | — | — | 1 | - |
| CHEMBL4101895 | — | — | 1 | - |
| CHEMBL4066621 | — | — | 1 | - |
| CHEMBL4078474 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4100811 | — | EC50 | = | 6630.0 | nM | 5.18 |
| CHEMBL4095529 | — | EC50 | > | 3450.0 | nM | - |
| CHEMBL4089725 | — | EC50 | > | 2760.0 | nM | - |
| CHEMBL4062672 | — | EC50 | > | 4240.0 | nM | - |
| CHEMBL4061597 | — | EC50 | > | 27600.0 | nM | - |
| CHEMBL4089717 | — | EC50 | > | 1170.0 | nM | - |
| CHEMBL4074049 | — | EC50 | > | 3690.0 | nM | - |
| CHEMBL4093101 | — | EC50 | > | 5920.0 | nM | - |
| CHEMBL4065430 | — | EC50 | > | 9210.0 | nM | - |
| CHEMBL4085345 | — | EC50 | > | 54400.0 | nM | - |
| CHEMBL4103275 | — | EC50 | > | 75200.0 | nM | - |
| CHEMBL4075094 | — | EC50 | > | 2970.0 | nM | - |
| CHEMBL4080133 | — | EC50 | > | 3850.0 | nM | - |
| CHEMBL4084357 | — | EC50 | > | 5150.0 | nM | - |
| CHEMBL4061608 | — | EC50 | > | 20100.0 | nM | - |
| CHEMBL4097283 | — | EC50 | > | 707000.0 | nM | - |
| CHEMBL4079259 | — | EC50 | > | 5150.0 | nM | - |
| CHEMBL4104988 | — | EC50 | > | 40400.0 | nM | - |
| CHEMBL4062507 | — | EC50 | > | 24100.0 | nM | - |
| CHEMBL4090492 | — | EC50 | > | 1190.0 | nM | - |
| CHEMBL4063892 | — | EC50 | > | 4930.0 | nM | - |
| CHEMBL4085465 | — | EC50 | > | 48700.0 | nM | - |
| CHEMBL4072495 | — | EC50 | > | 230000.0 | nM | - |
| CHEMBL4093229 | — | EC50 | > | 28600.0 | nM | - |
| CHEMBL4086331 | — | EC50 | > | 5610.0 | nM | - |
| CHEMBL4078474 | — | EC50 | > | 4880.0 | nM | - |
| CHEMBL4066621 | — | EC50 | > | 1800.0 | nM | - |
| CHEMBL4101895 | — | EC50 | >= | 1780.0 | nM | - |
| CHEMBL4075243 | — | EC50 | > | 3530.0 | nM | - |
| CHEMBL4078540 | — | EC50 | > | 3610.0 | nM | - |
| CHEMBL4096564 | — | EC50 | > | 2580.0 | nM | - |
| CHEMBL4101836 | — | EC50 | > | 4760.0 | nM | - |
| CHEMBL4083835 | — | EC50 | > | 2480.0 | nM | - |
| CHEMBL4094095 | — | EC50 | > | 6790.0 | nM | - |
| CHEMBL4077355 | — | EC50 | > | 7950.0 | nM | - |
| CHEMBL4059713 | — | EC50 | > | 3860.0 | nM | - |
| CHEMBL4076005 | — | EC50 | > | 3980.0 | nM | - |
| CHEMBL4094163 | — | EC50 | > | 2300.0 | nM | - |
| CHEMBL4102745 | — | EC50 | > | 4930.0 | nM | - |
| CHEMBL4067573 | — | EC50 | > | 3520.0 | nM | - |
| CHEMBL4094991 | — | EC50 | > | 2830.0 | nM | - |
| CHEMBL4069411 | — | EC50 | > | 2910.0 | nM | - |
| CHEMBL4090441 | — | EC50 | > | 2680.0 | nM | - |
| CHEMBL4060732 | — | EC50 | > | 2830.0 | nM | - |
| CHEMBL4082607 | — | EC50 | > | 2280.0 | nM | - |
| CHEMBL4088003 | — | EC50 | > | 4780.0 | nM | - |