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Assay Detail

CHEMBL4052871

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of recombinant human BRD1 (E556 to A688 residues) expressed in bacterial expression system by BROMOscan assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Bromodomain-containing protein 1 (CHEMBL2176774)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

A Versatile Method to Determine the Cellular Bioavailability of Small-Molecule Inhibitors.
Teuscher KB, Zhang M, Ji H.
J Med Chem (2017) 60 : 157 -169
PubMed 27935314 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 8.22 8.22

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4086276 1 8.22

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4086276 IC50 = 6.0 nM 8.22