Assay Detail
Binding
CHEMBL4052942
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Inhibition of NIK (unknown origin) after 1 to 2 hrs by ADP-FP assay
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Mitogen-activated protein kinase kinase kinase 14 (CHEMBL5888) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Structure-Based Design of Tricyclic NF-κB Inducing Kinase (NIK) Inhibitors That Have High Selectivity over Phosphoinositide-3-kinase (PI3K).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 30 | 7.57 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4098056 | — | — | 1 | 9.52 |
| CHEMBL4073390 | — | — | 1 | 9.40 |
| CHEMBL3692450 | — | — | 1 | 9.33 |
| CHEMBL3696566 | — | — | 1 | 9.10 |
| CHEMBL3692496 | — | — | 1 | 8.82 |
| CHEMBL3692396 | — | — | 1 | 8.70 |
| CHEMBL4065087 | — | — | 1 | 8.54 |
| CHEMBL3692493 | — | — | 1 | 8.52 |
| CHEMBL3692485 | — | — | 1 | 8.49 |
| CHEMBL3692400 | — | — | 1 | 8.15 |
| CHEMBL3692380 | — | — | 1 | 8.12 |
| CHEMBL3692429 | — | — | 1 | 8.06 |
| CHEMBL3696573 | — | — | 1 | 8.00 |
| CHEMBL3692529 | — | — | 1 | 7.70 |
| CHEMBL3692374 | — | — | 1 | 7.70 |
| CHEMBL3692360 | — | — | 1 | 7.55 |
| CHEMBL3692389 | — | — | 1 | 7.45 |
| CHEMBL3692362 | — | — | 1 | 7.44 |
| CHEMBL3692382 | — | — | 1 | 7.40 |
| CHEMBL3692391 | — | — | 1 | 7.39 |
| CHEMBL3692369 | — | — | 1 | 7.00 |
| CHEMBL3692388 | — | — | 1 | 6.70 |
| CHEMBL3692359 | — | — | 1 | 6.51 |
| CHEMBL3696567 | — | — | 1 | 6.39 |
| CHEMBL3696549 | — | — | 1 | 6.26 |
| CHEMBL3692406 | — | — | 1 | 6.01 |
| CHEMBL3696550 | — | — | 1 | 5.93 |
| CHEMBL4086137 | — | — | 1 | 5.89 |
| CHEMBL3692405 | — | — | 1 | 5.60 |
| CHEMBL3692412 | — | — | 1 | 5.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4098056 | — | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL4073390 | — | Ki | = | 0.4 | nM | 9.40 |
| CHEMBL3692450 | — | Ki | = | 0.47 | nM | 9.33 |
| CHEMBL3696566 | — | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL3692496 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL3692396 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL4065087 | — | Ki | = | 2.9 | nM | 8.54 |
| CHEMBL3692493 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL3692485 | — | Ki | = | 3.2 | nM | 8.49 |
| CHEMBL3692400 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL3692380 | — | Ki | = | 7.5 | nM | 8.12 |
| CHEMBL3692429 | — | Ki | = | 8.7 | nM | 8.06 |
| CHEMBL3696573 | — | Ki | = | 9.9 | nM | 8.00 |
| CHEMBL3692529 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL3692374 | — | Ki | = | 20.2 | nM | 7.70 |
| CHEMBL3692360 | — | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL3692389 | — | Ki | = | 35.5 | nM | 7.45 |
| CHEMBL3692362 | — | Ki | = | 36.0 | nM | 7.44 |
| CHEMBL3692382 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL3692391 | — | Ki | = | 41.0 | nM | 7.39 |
| CHEMBL3692369 | — | Ki | = | 101.0 | nM | 7.00 |
| CHEMBL3692388 | — | Ki | = | 201.0 | nM | 6.70 |
| CHEMBL3692359 | — | Ki | = | 310.0 | nM | 6.51 |
| CHEMBL3696567 | — | Ki | = | 405.0 | nM | 6.39 |
| CHEMBL3696549 | — | Ki | = | 547.0 | nM | 6.26 |
| CHEMBL3692406 | — | Ki | = | 986.0 | nM | 6.01 |
| CHEMBL3696550 | — | Ki | = | 1164.0 | nM | 5.93 |
| CHEMBL4086137 | — | Ki | = | 1280.0 | nM | 5.89 |
| CHEMBL3692405 | — | Ki | = | 2503.0 | nM | 5.60 |
| CHEMBL3692412 | — | Ki | = | 4282.0 | nM | 5.37 |