Assay Detail
ADMET
CHEMBL4052945
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Cytotoxicity against HEK293 cells assessed as effect on cell viability after 24 hrs by HSV-TK reporter assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure-Based Design of Tricyclic NF-κB Inducing Kinase (NIK) Inhibitors That Have High Selectivity over Phosphoinositide-3-kinase (PI3K).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 4.89 | 4.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3692450 | — | — | 1 | 4.89 |
| CHEMBL4098056 | — | — | 1 | - |
| CHEMBL4073390 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3692450 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL4098056 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4073390 | — | IC50 | > | 20000.0 | nM | - |