Assay Detail
Binding
CHEMBL4053009
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human BRPF3 expressed in Escherichia coli BL21 after 1 hr by BROMOscan assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Bromodomain and PHD finger-containing protein 3 (CHEMBL3108644) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design of a Biased Potent Small Molecule Inhibitor of the Bromodomain and PHD Finger-Containing (BRPF) Proteins Suitable for Cellular and in Vivo Studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.55 | 6.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4102050 | — | — | 1 | 6.58 |
| CHEMBL4076056 | — | — | 1 | 6.00 |
| CHEMBL4081438 | — | — | 1 | 5.64 |
| CHEMBL4067436 | — | — | 1 | 5.12 |
| CHEMBL4096095 | — | — | 1 | 5.03 |
| CHEMBL4078047 | — | — | 1 | 4.92 |
| CHEMBL4059509 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4102050 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL4076056 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4081438 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL4067436 | — | IC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL4096095 | — | IC50 | = | 9300.0 | nM | 5.03 |
| CHEMBL4078047 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL4059509 | — | IC50 | > | 100000.0 | nM | - |