Assay Detail
Binding
CHEMBL4053391
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of amyloid beta (1 to 42) (unknown origin) aggregation by Thioflavin-T fluorescence assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Combined in Vitro Cell-Based/in Silico Screening of Naturally Occurring Flavonoids and Phenolic Compounds as Potential Anti-Alzheimer Drugs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 4.61 | 4.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3348861 | AMPELOPSIN | 2.0 | 1 | 4.89 |
| CHEMBL164 | MYRICETIN | — | 1 | 4.83 |
| CHEMBL150 | KAEMPFEROL | 1.0 | 1 | 4.12 |
| CHEMBL50 | QUERCETIN | 3.0 | 1 | - |
| CHEMBL9323 | DIHYDROKAEMPFEROL | — | 1 | - |
| CHEMBL28 | APIGENIN | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3348861 | AMPELOPSIN | IC50 | = | 12800.0 | nM | 4.89 |
| CHEMBL164 | MYRICETIN | IC50 | = | 14800.0 | nM | 4.83 |
| CHEMBL150 | KAEMPFEROL | IC50 | = | 75100.0 | nM | 4.12 |
| CHEMBL50 | QUERCETIN | IC50 | = | 124600.0 | nM | - |
| CHEMBL9323 | DIHYDROKAEMPFEROL | IC50 | > | 500000.0 | nM | - |
| CHEMBL28 | APIGENIN | IC50 | = | 176200.0 | nM | - |