Assay Detail
Binding
CHEMBL4053416
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human PTP1B using pNPP as substrate after 30 mins
12
Total Activities
6
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Tyrosine-protein phosphatase non-receptor type 1 (CHEMBL335) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Glycybridins A-K, Bioactive Phenolic Compounds from Glycyrrhiza glabra.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.30 | 5.30 |
| Inhibition | 6 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL464581 | HISPAGLABRIDIN A | — | 2 | 5.30 |
| CHEMBL462721 | GLABROL | — | 2 | 5.30 |
| CHEMBL590635 | SHINFLAVANONE | — | 2 | 5.30 |
| CHEMBL2437376 | — | — | 2 | 5.30 |
| CHEMBL1644933 | KANZONOL C | — | 2 | 5.30 |
| CHEMBL4059903 | — | — | 2 | 5.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL464581 | HISPAGLABRIDIN A | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL462721 | GLABROL | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL590635 | SHINFLAVANONE | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL2437376 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL1644933 | KANZONOL C | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL4059903 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL464581 | HISPAGLABRIDIN A | Inhibition | - | % | - | |
| CHEMBL462721 | GLABROL | Inhibition | - | % | - | |
| CHEMBL590635 | SHINFLAVANONE | Inhibition | - | % | - | |
| CHEMBL2437376 | — | Inhibition | - | % | - | |
| CHEMBL1644933 | KANZONOL C | Inhibition | - | % | - | |
| CHEMBL4059903 | — | Inhibition | - | % | - |