Assay Detail
Functional
CHEMBL4053933
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Antiproliferative activity against human Raji cells over expressing BTK after 48 hrs by CCK-8 assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Raji |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design and synthesis of sulfonamide-substituted diphenylpyrimidines (SFA-DPPYs) as potent Bruton's tyrosine kinase (BTK) inhibitors with improved activity toward B-cell lymphoblastic leukemia.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 4.69 | 4.98 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4086899 | — | — | 1 | 4.98 |
| CHEMBL4065460 | — | — | 1 | 4.88 |
| CHEMBL4094611 | — | — | 1 | 4.85 |
| CHEMBL4061898 | — | — | 1 | 4.81 |
| CHEMBL4103300 | — | — | 1 | 4.76 |
| CHEMBL4097689 | — | — | 1 | 4.73 |
| CHEMBL4092347 | — | — | 1 | 4.73 |
| CHEMBL1873475 | IBRUTINIB | 4.0 | 1 | 4.71 |
| CHEMBL4089960 | — | — | 1 | 4.65 |
| CHEMBL3301625 | SPEBRUTINIB | 2.0 | 1 | 4.53 |
| CHEMBL4074077 | — | — | 1 | 4.47 |
| CHEMBL4070521 | — | — | 1 | 4.43 |
| CHEMBL4071567 | — | — | 1 | 4.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4086899 | — | IC50 | = | 10500.0 | nM | 4.98 |
| CHEMBL4065460 | — | IC50 | = | 13200.0 | nM | 4.88 |
| CHEMBL4094611 | — | IC50 | = | 14200.0 | nM | 4.85 |
| CHEMBL4061898 | — | IC50 | = | 15500.0 | nM | 4.81 |
| CHEMBL4103300 | — | IC50 | = | 17400.0 | nM | 4.76 |
| CHEMBL4097689 | — | IC50 | = | 18700.0 | nM | 4.73 |
| CHEMBL4092347 | — | IC50 | = | 18700.0 | nM | 4.73 |
| CHEMBL1873475 | IBRUTINIB | IC50 | = | 19300.0 | nM | 4.71 |
| CHEMBL4089960 | — | IC50 | = | 22400.0 | nM | 4.65 |
| CHEMBL3301625 | SPEBRUTINIB | IC50 | = | 29400.0 | nM | 4.53 |
| CHEMBL4074077 | — | IC50 | = | 34100.0 | nM | 4.47 |
| CHEMBL4070521 | — | IC50 | = | 36900.0 | nM | 4.43 |
| CHEMBL4071567 | — | IC50 | = | 40900.0 | nM | 4.39 |