Assay Detail
Functional
CHEMBL4054096
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Antiproliferative activity against human HCT116 cells after 72 hrs by MTT assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Scutellarin derivatives as apoptosis inducers: Design, synthesis and biological evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 5.28 | 5.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4079050 | — | — | 1 | 5.90 |
| CHEMBL4077450 | — | — | 1 | 5.76 |
| CHEMBL4084401 | — | — | 1 | 5.67 |
| CHEMBL4102367 | — | — | 1 | 5.61 |
| CHEMBL4091087 | — | — | 1 | 5.59 |
| CHEMBL185 | FLUOROURACIL | 4.0 | 1 | 5.38 |
| CHEMBL4081307 | — | — | 1 | 5.24 |
| CHEMBL4068994 | — | — | 1 | 5.14 |
| CHEMBL4062766 | — | — | 1 | 4.87 |
| CHEMBL4086904 | — | — | 1 | 4.76 |
| CHEMBL487805 | SCUTELLARIN | — | 1 | 4.11 |
| CHEMBL4103309 | — | — | 1 | - |
| CHEMBL4065473 | — | — | 1 | - |
| CHEMBL4059547 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4079050 | — | IC50 | = | 1270.0 | nM | 5.90 |
| CHEMBL4077450 | — | IC50 | = | 1740.0 | nM | 5.76 |
| CHEMBL4084401 | — | IC50 | = | 2160.0 | nM | 5.67 |
| CHEMBL4102367 | — | IC50 | = | 2460.0 | nM | 5.61 |
| CHEMBL4091087 | — | IC50 | = | 2590.0 | nM | 5.59 |
| CHEMBL185 | FLUOROURACIL | IC50 | = | 4160.0 | nM | 5.38 |
| CHEMBL4081307 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL4068994 | — | IC50 | = | 7250.0 | nM | 5.14 |
| CHEMBL4062766 | — | IC50 | = | 13580.0 | nM | 4.87 |
| CHEMBL4086904 | — | IC50 | = | 17400.0 | nM | 4.76 |
| CHEMBL487805 | SCUTELLARIN | IC50 | = | 77000.0 | nM | 4.11 |
| CHEMBL4103309 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4065473 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4059547 | — | IC50 | > | 50000.0 | nM | - |