Assay Detail
Functional
CHEMBL4054626
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Antiviral activity against Influenza A virus A/Ned/378/05(H1N1) infected in MDCK cells assessed as host cell viability measured after 3 to 6 days post infection by MTS assay
37
Total Activities
37
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Influenza A virus |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Host dihydrofolate reductase (DHFR)-directed cycloguanil analogues endowed with activity against influenza virus and respiratory syncytial virus.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 37 | 5.35 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL959 | RIMANTADINE | 4.0 | 1 | 7.30 |
| CHEMBL222813 | ZANAMIVIR | 4.0 | 1 | 6.70 |
| CHEMBL92583 | CHLORCYCLOGUANIL | — | 1 | 6.46 |
| CHEMBL6948 | — | — | 1 | 6.22 |
| CHEMBL7130 | — | — | 1 | 6.07 |
| CHEMBL660 | AMANTADINE | 4.0 | 1 | 5.66 |
| CHEMBL6741 | — | — | 1 | 5.14 |
| CHEMBL1643 | RIBAVIRIN | 4.0 | 1 | 5.12 |
| CHEMBL6742 | — | — | 1 | 4.85 |
| CHEMBL7005 | — | — | 1 | 4.62 |
| CHEMBL747 | CYCLOGUANIL | 2.0 | 1 | 4.54 |
| CHEMBL7004 | — | — | 1 | 4.47 |
| CHEMBL36 | PYRIMETHAMINE | 4.0 | 1 | 4.46 |
| CHEMBL266573 | — | — | 1 | 4.43 |
| CHEMBL345146 | — | — | 1 | 4.17 |
| CHEMBL582150 | — | — | 1 | - |
| CHEMBL549103 | — | — | 1 | - |
| CHEMBL4102917 | — | — | 1 | - |
| CHEMBL4078639 | — | — | 1 | - |
| CHEMBL574656 | — | — | 1 | - |
| CHEMBL21979 | — | — | 1 | - |
| CHEMBL4105317 | — | — | 1 | - |
| CHEMBL93484 | — | — | 1 | - |
| CHEMBL90703 | — | — | 1 | - |
| CHEMBL93889 | — | — | 1 | - |
| CHEMBL533117 | — | — | 1 | - |
| CHEMBL1377 | PROGUANIL | 4.0 | 1 | - |
| CHEMBL840 | 4-CHLOROPHENYLBIGUANIDE | — | 1 | - |
| CHEMBL22 | TRIMETHOPRIM | 4.0 | 1 | - |
| CHEMBL582902 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL959 | RIMANTADINE | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL222813 | ZANAMIVIR | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL92583 | CHLORCYCLOGUANIL | EC50 | = | 350.0 | nM | 6.46 |
| CHEMBL6948 | — | EC50 | = | 600.0 | nM | 6.22 |
| CHEMBL7130 | — | EC50 | = | 850.0 | nM | 6.07 |
| CHEMBL660 | AMANTADINE | EC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL6741 | — | EC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL1643 | RIBAVIRIN | EC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL6742 | — | EC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL7005 | — | EC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL747 | CYCLOGUANIL | EC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL7004 | — | EC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL36 | PYRIMETHAMINE | EC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL266573 | — | EC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL345146 | — | EC50 | = | 68000.0 | nM | 4.17 |
| CHEMBL6613 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL267499 | — | EC50 | - | — | - | |
| CHEMBL268088 | — | EC50 | - | — | - | |
| CHEMBL326709 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL318133 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL549146 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL3040167 | — | EC50 | - | — | - | |
| CHEMBL582150 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL549103 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4102917 | — | EC50 | - | — | - | |
| CHEMBL4078639 | — | EC50 | - | — | - | |
| CHEMBL574656 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL21979 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4105317 | — | EC50 | - | — | - | |
| CHEMBL93484 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL90703 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL93889 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL533117 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL1377 | PROGUANIL | EC50 | > | 100000.0 | nM | - |
| CHEMBL840 | 4-CHLOROPHENYLBIGUANIDE | EC50 | > | 100000.0 | nM | - |
| CHEMBL22 | TRIMETHOPRIM | EC50 | > | 100000.0 | nM | - |
| CHEMBL582902 | — | EC50 | - | — | - |