Assay Detail
Functional
CHEMBL4054627
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against Influenza A virus A/Ned/378/05(H1N1) infected in MDCK cells assessed as inhibition of viral-induced cytopathic effect measured after 3 to 6 days post infection by formazan-based colorimetric assay
37
Total Activities
37
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Influenza A virus |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Host dihydrofolate reductase (DHFR)-directed cycloguanil analogues endowed with activity against influenza virus and respiratory syncytial virus.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 37 | 5.14 | 6.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL959 | RIMANTADINE | 4.0 | 1 | 6.50 |
| CHEMBL92583 | CHLORCYCLOGUANIL | — | 1 | 6.26 |
| CHEMBL222813 | ZANAMIVIR | 4.0 | 1 | 6.10 |
| CHEMBL7130 | — | — | 1 | 5.96 |
| CHEMBL6948 | — | — | 1 | 5.96 |
| CHEMBL660 | AMANTADINE | 4.0 | 1 | 5.64 |
| CHEMBL1643 | RIBAVIRIN | 4.0 | 1 | 5.00 |
| CHEMBL36 | PYRIMETHAMINE | 4.0 | 1 | 4.82 |
| CHEMBL6741 | — | — | 1 | 4.68 |
| CHEMBL747 | CYCLOGUANIL | 2.0 | 1 | 4.48 |
| CHEMBL7005 | — | — | 1 | 4.39 |
| CHEMBL6742 | — | — | 1 | 4.37 |
| CHEMBL345146 | — | — | 1 | 4.35 |
| CHEMBL7004 | — | — | 1 | 4.32 |
| CHEMBL266573 | — | — | 1 | 4.20 |
| CHEMBL4078639 | — | — | 1 | - |
| CHEMBL574656 | — | — | 1 | - |
| CHEMBL582902 | — | — | 1 | - |
| CHEMBL268088 | — | — | 1 | - |
| CHEMBL93484 | — | — | 1 | - |
| CHEMBL90703 | — | — | 1 | - |
| CHEMBL93889 | — | — | 1 | - |
| CHEMBL533117 | — | — | 1 | - |
| CHEMBL1377 | PROGUANIL | 4.0 | 1 | - |
| CHEMBL840 | 4-CHLOROPHENYLBIGUANIDE | — | 1 | - |
| CHEMBL6613 | — | — | 1 | - |
| CHEMBL22 | TRIMETHOPRIM | 4.0 | 1 | - |
| CHEMBL326709 | — | — | 1 | - |
| CHEMBL549146 | — | — | 1 | - |
| CHEMBL4105317 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL959 | RIMANTADINE | EC50 | = | 320.0 | nM | 6.50 |
| CHEMBL92583 | CHLORCYCLOGUANIL | EC50 | = | 550.0 | nM | 6.26 |
| CHEMBL222813 | ZANAMIVIR | EC50 | = | 800.0 | nM | 6.10 |
| CHEMBL7130 | — | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL6948 | — | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL660 | AMANTADINE | EC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL1643 | RIBAVIRIN | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL36 | PYRIMETHAMINE | EC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL6741 | — | EC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL747 | CYCLOGUANIL | EC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL7005 | — | EC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL6742 | — | EC50 | = | 43000.0 | nM | 4.37 |
| CHEMBL345146 | — | EC50 | = | 45000.0 | nM | 4.35 |
| CHEMBL7004 | — | EC50 | = | 48000.0 | nM | 4.32 |
| CHEMBL266573 | — | EC50 | = | 63000.0 | nM | 4.20 |
| CHEMBL267499 | — | EC50 | - | — | - | |
| CHEMBL318133 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL21979 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL3040167 | — | EC50 | - | — | - | |
| CHEMBL582150 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL549103 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4102917 | — | EC50 | - | — | - | |
| CHEMBL4078639 | — | EC50 | - | — | - | |
| CHEMBL574656 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL582902 | — | EC50 | - | — | - | |
| CHEMBL268088 | — | EC50 | - | — | - | |
| CHEMBL93484 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL90703 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL93889 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL533117 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL1377 | PROGUANIL | EC50 | > | 100000.0 | nM | - |
| CHEMBL840 | 4-CHLOROPHENYLBIGUANIDE | EC50 | > | 100000.0 | nM | - |
| CHEMBL6613 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL22 | TRIMETHOPRIM | EC50 | > | 100000.0 | nM | - |
| CHEMBL326709 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL549146 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4105317 | — | EC50 | - | — | - |