Assay Detail
Binding
CHEMBL4055338
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of 5-carboxyfluorescein-GY(PO3H2)LVLDKW from STAT5A SH2 domain (unknown origin) pretreated for 1 hr followed by fluorescent tracer addition after 1 hr by fluorescence polarization assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Signal transducer and activator of transcription 5A (CHEMBL5403) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Halogen-substituted catechol bisphosphates are potent and selective inhibitors of the transcription factor STAT5b.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.06 | 5.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4104462 | — | — | 1 | 5.14 |
| CHEMBL4104019 | — | — | 1 | 5.14 |
| CHEMBL4077592 | — | — | 1 | 5.13 |
| CHEMBL4085646 | — | — | 1 | 5.12 |
| CHEMBL4103576 | — | — | 1 | 5.08 |
| CHEMBL4093849 | — | — | 1 | 5.08 |
| CHEMBL4080740 | — | — | 1 | 5.07 |
| CHEMBL4080219 | — | — | 1 | 5.05 |
| CHEMBL4075745 | — | — | 1 | 5.04 |
| CHEMBL4066274 | — | — | 1 | 5.01 |
| CHEMBL4076474 | — | — | 1 | 4.98 |
| CHEMBL4086096 | — | — | 1 | 4.97 |
| CHEMBL4062751 | — | — | 1 | 4.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4104462 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL4104019 | — | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL4077592 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL4085646 | — | IC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL4103576 | — | IC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL4093849 | — | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL4080740 | — | IC50 | = | 8600.0 | nM | 5.07 |
| CHEMBL4080219 | — | IC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL4075745 | — | IC50 | = | 9100.0 | nM | 5.04 |
| CHEMBL4066274 | — | IC50 | = | 9700.0 | nM | 5.01 |
| CHEMBL4076474 | — | IC50 | = | 10500.0 | nM | 4.98 |
| CHEMBL4086096 | — | IC50 | = | 10600.0 | nM | 4.97 |
| CHEMBL4062751 | — | IC50 | = | 11900.0 | nM | 4.92 |