Assay Detail
Binding
CHEMBL4055868
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of 5-carboxyfluorescein-GpYDKPHVL-OH binding to STAT1 (unknown origin) pre-incubated for 1 hr before fluorescent-labelled peptide addition by fluorescence polarization assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Signal transducer and activator of transcription 1-alpha/beta (CHEMBL6101) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
A small-molecule screen identifies the antitrypanosomal agent suramin and analogues NF023 and NF449 as inhibitors of STAT5a/b.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 4.87 | 5.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1253351 | — | — | 1 | 5.10 |
| CHEMBL413376 | SURAMIN HEXASODIUM | 3.0 | 1 | 5.04 |
| CHEMBL4082141 | — | — | 1 | 4.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1253351 | — | IC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL413376 | SURAMIN HEXASODIUM | IC50 | = | 9100.0 | nM | 5.04 |
| CHEMBL4082141 | — | IC50 | = | 33200.0 | nM | 4.48 |