Compound Detail
CHEMBL413376
SURAMIN HEXASODIUM 🧪 Phase III
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🧪 Phase III
Cc1ccc(C(=O)Nc2ccc(S(=O)(=O)[O-])c3cc(S(=O)(=O)[O-])cc(S(=O)(=O)[O-])c23)cc1NC(=O)c1cccc(NC(=O)Nc2cccc(C(=O)Nc3cc(C(=O)Nc4ccc(S(=O)(=O)[O-])c5cc(S(=O)(=O)[O-])cc(S(=O)(=O)[O-])c45)ccc3C)c2)c1.[Na+].[Na+].[Na+].[Na+].[Na+].[Na+]
Basic Information
| ChEMBL ID | CHEMBL413376 |
| Name | SURAMIN HEXASODIUM |
| Phase | Phase III |
| Structure Type | MOL |
| InChI Key | VAPNKLKDKUDFHK-UHFFFAOYSA-H |
| Parent Compound | CHEMBL265502 |
| Active Moiety | CHEMBL265502 |
13
Targets
20
Activities
2
Assay Types
0
PK Parameters
20
Publications
14
Known Names
15
Indications
1
Mechanisms
Molecular Properties
1297.3
MW (Da)
Drug Information
| Molecule Type | Small molecule |
| Chirality | Achiral |
Mechanism of Action
| Mechanism | Action Type | Target | Direct | Efficacy |
|---|---|---|---|---|
| Acidic fibroblast growth factor inhibitor | INHIBITOR | Fibroblast growth factor 1 | ✓ | ✓ |
Indications
Leishmaniasis Prostatic Neoplasms, Castration-Resistant Trypanosomiasis Acute Kidney Injury Adrenal Cortex Neoplasms Carcinoma, Non-Small-Cell Lung Central Nervous System Neoplasms Child Development Disorders, Pervasive Multiple Myeloma Prostatic Neoplasms Breast Neoplasms Carcinoma, Renal Cell Colorectal Neoplasms Hand, Foot and Mouth Disease Urinary Bladder Neoplasms
ATC Classification
P01CX02
suramin sodium
Level 1: ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS
Level 2: ANTIPROTOZOALS
Activity Summary
IC50 17 meas. best 7.37
EC50 3 meas. best 7.57
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Unchecked CHEMBL612545 | EC50 | 7.57 | 7.57 | 27.0 | 1 |
| Trypanosoma brucei CHEMBL612849 | IC50 | 7.37 | 7.37 | 43.0 | 1 |
| NAD-dependent protein deacetylase sirtuin-1 CHEMBL4506 | IC50 | 6.52 | 6.52 | 300.0 | 1 |
| Trypanosoma brucei brucei CHEMBL612851 | IC50 | 6.52 | 6.5133 | 300.0 | 3 |
| dengue virus type 2 CHEMBL613966 | EC50 | 6.46 | 6.46 | 350.0 | 1 |
| NAD-dependent protein deacetylase sirtuin-2 CHEMBL4462 | IC50 | 5.92 | 5.92 | 1200.0 | 2 |
| P2Y purinoceptor 13 CHEMBL3321651 | IC50 | 5.64 | 5.64 | 2300.0 | 1 |
| Replicase polyprotein 1ab CHEMBL4523582 | IC50 | 5.19 | 5.19 | 6500.0 | 1 |
| Human immunodeficiency virus 1 CHEMBL378 | EC50 | 5.09 | 5.09 | 8200.0 | 1 |
| Signal transducer and activator of transcription 1-alpha/beta CHEMBL6101 | IC50 | 5.04 | 5.04 | 9100.0 | 1 |
| Signal transducer and activator of transcription 5A CHEMBL5403 | IC50 | 5.03 | 5.03 | 9400.0 | 1 |
| Plasmodium falciparum CHEMBL364 | IC50 | 5.0 | 4.92 | 10000.0 | 5 |
| Signal transducer and activator of transcription 5B CHEMBL5817 | IC50 | 4.98 | 4.98 | 10400.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 19734910 | 10.1038/nchembio.215 | Plasmodium falciparum | 5 |
| - | 10.6019/CHEMBL5724709 | Fibroblast | 2 |
| - | 10.6019/CHEMBL4495565 | SARS-CoV-2 | 2 |
| 31727469 | 10.1016/j.ejmech.2019.111789 | P2Y purinoceptor 2 | 2 |
| 31727469 | 10.1016/j.ejmech.2019.111789 | Uracil nucleotide/cysteinyl leukotriene receptor | 2 |
| 28624143 | 10.1016/j.bmcl.2017.06.012 | Signal transducer and activator of transcription 5A | 2 |
| - | 10.6019/CHEMBL4808148 | Histone deacetylase 6 | 2 |
| - | 10.6019/CHEMBL5724709 | U2OS | 2 |
| - | 10.6019/CHEMBL5724709 | HEK-293T | 2 |
| 16516467 | 10.1016/j.bmcl.2006.02.026 | J774 | 2 |
| 16516467 | 10.1016/j.bmcl.2006.02.026 | Trypanosoma brucei brucei | 2 |
| 8336338 | 10.1021/jm00066a008 | Human immunodeficiency virus 1 | 2 |
| 21306904 | 10.1016/j.bmc.2011.01.010 | Trypanosoma brucei brucei | 1 |
| - | 10.6019/CHEMBL5724796 | Bromodomain-containing protein 4 | 1 |
| 21080630 | 10.1021/jm100861p | NAD-dependent protein deacetylase sirtuin-2 | 1 |
| 21080630 | 10.1021/jm100861p | NAD-dependent protein deacetylase sirtuin-1 | 1 |
| 25515955 | 10.1016/j.bmc.2014.11.027 | NAD-dependent protein deacetylase sirtuin-2 | 1 |
| 26258852 | 10.1021/acs.jmedchem.5b00762 | Unchecked | 1 |
| 17417631 | 10.1038/nchembio873 | Unchecked | 1 |
| 16516467 | 10.1016/j.bmcl.2006.02.026 | Rhodesain | 1 |
Data from ChEMBL 36 via Core Engine