Assay Detail
Functional
CHEMBL819158
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In vitro anti-protozoal parasite activity against Trypanosoma brucei TB-1
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
1,4-Dihydroxy-2,3-dioxatricyclo[8.4.0.0(4,9)]tetradecane and derivatives with in vitro activity against Plasmodium falciparum, Trypanasoma b brucei, Trypanasoma cruzi, and Leishmaniasis infantum.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.29 | 7.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL413376 | SURAMIN HEXASODIUM | 3.0 | 1 | 7.37 |
| CHEMBL59755 | — | — | 1 | 5.40 |
| CHEMBL60505 | — | — | 1 | 5.00 |
| CHEMBL60144 | — | — | 1 | 4.89 |
| CHEMBL60487 | — | — | 1 | 4.80 |
| CHEMBL60085 | — | — | 1 | 4.80 |
| CHEMBL61588 | — | — | 1 | 4.77 |
| CHEMBL60093 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL413376 | SURAMIN HEXASODIUM | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL59755 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL60505 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL60144 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL60487 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL60085 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL61588 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL60093 | — | IC50 | < | 64000.0 | nM | - |