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Assay Detail

CHEMBL890919

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antitrypanosomal activity against Trypanosoma brucei brucei after 48 hrs
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Trypanosoma brucei brucei
Confidence 1 — Organism
Curated By Intermediate

Target

Trypanosoma brucei brucei (CHEMBL612851)
Type ORGANISM
Organism Trypanosoma brucei brucei

Publication

Antitrypanosomal activity of quaternary naphthalimide derivatives.
Muth M, Hoerr V, Glaser M, Ponte-Sucre A, Moll H, Stich A, Holzgrabe U.
Bioorg Med Chem Lett (2007) 17 : 1590 -1593
PubMed 17239596 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 14 5.72 8.57

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL361506 PENTAMIDINE ISETHIONATE 4.0 1 8.57
CHEMBL388891 1 7.52
CHEMBL413376 SURAMIN HEXASODIUM 3.0 1 6.52
CHEMBL389344 1 6.16
CHEMBL8532 1 5.93
CHEMBL233476 1 5.92
CHEMBL269592 1 5.37
CHEMBL406691 1 5.33
CHEMBL390702 1 5.22
CHEMBL397958 1 5.06
CHEMBL388470 1 4.64
CHEMBL830 EFLORNITHINE 4.0 1 4.64
CHEMBL233049 1 4.62
CHEMBL8449 1 4.55

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL361506 PENTAMIDINE ISETHIONATE IC50 = 2.7 nM 8.57
CHEMBL388891 IC50 = 30.0 nM 7.52
CHEMBL413376 SURAMIN HEXASODIUM IC50 = 300.0 nM 6.52
CHEMBL389344 IC50 = 690.0 nM 6.16
CHEMBL8532 IC50 = 1170.0 nM 5.93
CHEMBL233476 IC50 = 1200.0 nM 5.92
CHEMBL269592 IC50 = 4270.0 nM 5.37
CHEMBL406691 IC50 = 4620.0 nM 5.33
CHEMBL390702 IC50 = 5950.0 nM 5.22
CHEMBL397958 IC50 = 8780.0 nM 5.06
CHEMBL388470 IC50 = 22890.0 nM 4.64
CHEMBL830 EFLORNITHINE IC50 = 22900.0 nM 4.64
CHEMBL233049 IC50 = 24250.0 nM 4.62
CHEMBL8449 IC50 = 27930.0 nM 4.55