Assay Detail
Functional
CHEMBL2033738
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antitrypanosomal activity against Trypanosoma brucei brucei TC221 infected in mouse J774.1 cells after 48 hrs by alamar blue assay
35
Total Activities
35
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei brucei |
| Cell Type | J774.1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and structure-activity relationships of new quinolone-type molecules against Trypanosoma brucei.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 33 | 5.90 | 8.59 |
| Activity | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL166 | MELARSOPROL | 3.0 | 1 | 8.59 |
| CHEMBL361506 | PENTAMIDINE ISETHIONATE | 4.0 | 1 | 8.54 |
| CHEMBL2031131 | — | — | 1 | 7.33 |
| CHEMBL413376 | SURAMIN HEXASODIUM | 3.0 | 1 | 6.51 |
| CHEMBL2031127 | — | — | 1 | 6.27 |
| CHEMBL2031128 | — | — | 1 | 6.17 |
| CHEMBL2031130 | — | — | 1 | 6.17 |
| CHEMBL2031123 | — | — | 1 | 6.12 |
| CHEMBL2031121 | — | — | 1 | 6.11 |
| CHEMBL2031118 | — | — | 1 | 5.99 |
| CHEMBL2031122 | — | — | 1 | 5.97 |
| CHEMBL2031124 | — | — | 1 | 5.96 |
| CHEMBL2031120 | — | — | 1 | 5.64 |
| CHEMBL2031119 | — | — | 1 | 5.56 |
| CHEMBL2031126 | — | — | 1 | 5.51 |
| CHEMBL2031125 | — | — | 1 | 5.51 |
| CHEMBL2031117 | — | — | 1 | 5.34 |
| CHEMBL2031129 | — | — | 1 | 5.27 |
| CHEMBL2031108 | — | — | 1 | 5.14 |
| CHEMBL2031116 | — | — | 1 | 5.05 |
| CHEMBL2031112 | — | — | 1 | 4.84 |
| CHEMBL2031114 | — | — | 1 | 4.76 |
| CHEMBL2031113 | — | — | 1 | 4.72 |
| CHEMBL1201037 | EFLORNITHINE HYDROCHLORIDE | 4.0 | 1 | 4.64 |
| CHEMBL2031110 | — | — | 1 | - |
| CHEMBL2031109 | — | — | 1 | - |
| CHEMBL2031111 | — | — | 1 | - |
| CHEMBL2031107 | — | — | 1 | - |
| CHEMBL2031106 | — | — | 1 | - |
| CHEMBL2031105 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL166 | MELARSOPROL | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL361506 | PENTAMIDINE ISETHIONATE | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL2031131 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL413376 | SURAMIN HEXASODIUM | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL2031127 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL2031128 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL2031130 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL2031123 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL2031121 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL2031118 | — | IC50 | = | 1030.0 | nM | 5.99 |
| CHEMBL2031122 | — | IC50 | = | 1070.0 | nM | 5.97 |
| CHEMBL2031124 | — | IC50 | = | 1090.0 | nM | 5.96 |
| CHEMBL2031120 | — | IC50 | = | 2280.0 | nM | 5.64 |
| CHEMBL2031119 | — | IC50 | = | 2750.0 | nM | 5.56 |
| CHEMBL2031125 | — | IC50 | = | 3070.0 | nM | 5.51 |
| CHEMBL2031126 | — | IC50 | = | 3090.0 | nM | 5.51 |
| CHEMBL2031117 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL2031129 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL2031108 | — | IC50 | = | 7310.0 | nM | 5.14 |
| CHEMBL2031116 | — | IC50 | = | 8890.0 | nM | 5.05 |
| CHEMBL2031112 | — | IC50 | = | 14600.0 | nM | 4.84 |
| CHEMBL2031114 | — | IC50 | = | 17200.0 | nM | 4.76 |
| CHEMBL2031113 | — | IC50 | = | 19200.0 | nM | 4.72 |
| CHEMBL1201037 | EFLORNITHINE HYDROCHLORIDE | IC50 | = | 22900.0 | nM | 4.64 |
| CHEMBL2031132 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL2031115 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL550018 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL1958275 | — | Activity | - | — | - | |
| CHEMBL2031104 | — | Activity | - | — | - | |
| CHEMBL2031105 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL2031106 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL2031107 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL2031111 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL2031109 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL2031110 | — | IC50 | > | 40000.0 | nM | - |