Skip to main content
Free research Free research Free compound review with research home and workspace preview
Quick search ChEMBL 36
Compound Detail

CHEMBL1201037

EFLORNITHINE HYDROCHLORIDE
💊 Approved Drug
Enter ChEMBL ID:
Free Research Context This compound will appear in recent viewed items on the research home for this browser.
Research home View demo workspace
💊 Approved Drug
Cl.NCCCC(N)(C(=O)O)C(F)F.O
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL1201037
Name EFLORNITHINE HYDROCHLORIDE
Phase Approved
Structure Type MOL
InChI Key FJPAMFNRCFEGSD-UHFFFAOYSA-N
Therapeutic ✓ Yes
Parent Compound CHEMBL830
Active Moiety CHEMBL830

Known Names

Dfmo hcl Difluromethylornithine Eflornithine hcl Eflornithine hydrochloride Eflornithine hydrochloride monohydrate Iwilfin MDL 71,782 A MDL-71782-A MDL-71782A NSC-270295 NSC-337250 Ornidyl +2 more
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
19
Publications
14
Known Names
3
Indications
1
Mechanisms

Molecular Properties

182.2
MW (Da)
-0.23
ALogP
3
HBA
3
HBD
89.3
PSA (Ų)
0.55
QED
0
Ro5 Violations
5
Rot. Bonds

Drug Information

Molecule Type Small molecule
First Approval 1990
Availability Prescription
Chirality Racemic

Routes of Administration

Oral Parenteral Topical
USAN Stem ef-
USAN Year 1986

Extended Properties

Molecular Formula C6H15ClF2N2O3
MW 236.65
Aromatic Rings 0
Heavy Atoms 12
NP-Likeness 0.78

Mechanism of Action

Mechanism Action Type Target Direct Efficacy
Ornithine decarboxylase inhibitor INHIBITOR Ornithine decarboxylase ✓ ✓

Indications

Hirsutism Adenomatous Polyposis Coli Neuroblastoma

Activity Summary

IC50 2 meas. best 4.64

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Trypanosoma brucei brucei
CHEMBL612851
 IC50 4.64 4.64 22900.0 2

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Trypanosoma brucei brucei IC50 = 22900.0 nM 4.64 Trypanocidal activity against Trypanosoma brucei brucei after 48 hrs 16516467
Trypanosoma brucei brucei IC50 = 22900.0 nM 4.64 Antitrypanosomal activity against Trypanosoma brucei brucei TC221 infected in mo... 22376072

Literature References

PubMed DOI Target Context # Activities
- 10.6019/CHEMBL4495565 SARS-CoV-2 4
- 10.6019/CHEMBL4495564 Replicase polyprotein 1ab 2
- 10.6019/CHEMBL4808148 Histone deacetylase 6 2
16516467 10.1016/j.bmcl.2006.02.026 Trypanosoma brucei brucei 2
16516467 10.1016/j.bmcl.2006.02.026 J774 2
23956101 10.1093/toxsci/kft176 Bile salt export pump 1
23956101 10.1093/toxsci/kft176 ATP-binding cassette sub-family C member 2 1
23956101 10.1093/toxsci/kft176 ATP-binding cassette sub-family C member 3 1
23956101 10.1093/toxsci/kft176 ATP-binding cassette sub-family C member 4 1
- 10.21203/rs.3.rs-23951/v1 SARS-CoV-2 1
22376072 10.1021/jm101439s Trypanosoma brucei brucei 1
16516467 10.1016/j.bmcl.2006.02.026 Rhodesain 1
- 10.6019/CHEMBL4513149 Candida albicans 1
- 10.6019/CHEMBL4513149 Cryptococcus neoformans 1
- 10.6019/CHEMBL4513149 Escherichia coli 1
- 10.6019/CHEMBL4513149 Klebsiella pneumoniae 1
- 10.6019/CHEMBL4513149 Pseudomonas aeruginosa 1
- 10.6019/CHEMBL4513149 Acinetobacter baumannii 1
- 10.6019/CHEMBL4513149 Staphylococcus aureus 1

Data from ChEMBL 36 via Core Engine