Assay Detail
Functional
CHEMBL4055874
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Inhibition of human urotensin II-induced contraction in Sprague-Dawley rat aortic rings assessed as Emax for urotensin II relative to KCl-induced contraction (Rvb = 8.59 +/- 0.08 No_unit)
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Aorta |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Urotensin core mimics that modulate the biological activity of urotensin-II related peptide but not urotensin-II.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 8.62 | 8.87 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4101776 | — | — | 1 | 8.87 |
| CHEMBL4065900 | — | — | 1 | 8.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4101776 | — | EC50 | = | 1.349 | nM | 8.87 |
| CHEMBL4065900 | — | EC50 | = | 4.266 | nM | 8.37 |