Assay Detail
Functional
CHEMBL4055875
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Inhibition of urotensin II-related peptide-induced contraction in Sprague-Dawley rat aortic rings assessed as Emax for urotensin II-related peptide relative to KCl-induced contraction (Rvb = 8.07 +/- 0.03 No_unit)
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Aorta |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Urotensin core mimics that modulate the biological activity of urotensin-II related peptide but not urotensin-II.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 8.91 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4065900 | — | — | 1 | 9.30 |
| CHEMBL4101776 | — | — | 1 | 8.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4065900 | — | EC50 | = | 0.5012 | nM | 9.30 |
| CHEMBL4101776 | — | EC50 | = | 3.02 | nM | 8.52 |