Assay Detail
ADMET
CHEMBL4056601
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of CYP17 lyase in human hepatocyte microsomes using 17a-hydroxypregnenolone substrate by HPLC/MS/MS method
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Subcellular | Microsomes |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Steroid 17-alpha-hydroxylase/17,20 lyase (CHEMBL3522) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design and optimization of highly-selective, broad spectrum fungal CYP51 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.90 | 7.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1397 | POSACONAZOLE | 4.0 | 1 | 7.38 |
| CHEMBL4077246 | — | — | 1 | 4.42 |
| CHEMBL106 | FLUCONAZOLE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1397 | POSACONAZOLE | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL4077246 | — | IC50 | = | 38000.0 | nM | 4.42 |
| CHEMBL106 | FLUCONAZOLE | IC50 | > | 200000.0 | nM | - |