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Assay Detail

CHEMBL4056639

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiviral activity against wild type HIV1 3B infected in human MT4 cells assessed as inhibition of virus-induced cytopathic effect after 5 days by MTT assay
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Human immunodeficiency virus 1
Confidence 1 — Organism
Curated By Autocuration

Target

Human immunodeficiency virus 1 (CHEMBL378)
Type ORGANISM
Organism Human immunodeficiency virus 1

Publication

Discovery of novel DAPY-IAS hybrid derivatives as potential HIV-1 inhibitors using molecular hybridization based on crystallographic overlays.
Huang B, Wang X, Liu X, Chen Z, Li W, Sun S, Liu H, Daelemans D, De Clercq E, Pannecouque C, Zhan P, Liu X.
Bioorg Med Chem (2017) 25 : 4397 -4406
PubMed 28659246 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 27 5.79 8.89

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL231281 1 8.89
CHEMBL85059 1 8.59
CHEMBL308954 ETRAVIRINE 4.0 1 8.40
CHEMBL4061134 1 5.83
CHEMBL4065312 1 5.79
CHEMBL141 LAMIVUDINE 4.0 1 5.59
CHEMBL4083944 1 5.31
CHEMBL4102225 1 5.22
CHEMBL4102339 1 5.21
CHEMBL4073925 1 5.12
CHEMBL4086744 1 4.41
CHEMBL4081492 1 4.33
CHEMBL4097074 1 4.31
CHEMBL1460 DIDANOSINE 4.0 1 4.12
CHEMBL4094486 1 -
CHEMBL4076724 1 -
CHEMBL4059524 1 -
CHEMBL4064287 1 -
CHEMBL4092014 1 -
CHEMBL4070909 1 -
CHEMBL4084260 1 -
CHEMBL4064984 1 -
CHEMBL4086444 1 -
CHEMBL4091707 1 -
CHEMBL4063941 1 -
CHEMBL4098005 1 -
CHEMBL4101937 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL231281 EC50 = 1.3 nM 8.89
CHEMBL85059 EC50 = 2.6 nM 8.59
CHEMBL308954 ETRAVIRINE EC50 = 4.0 nM 8.40
CHEMBL4061134 EC50 = 1480.0 nM 5.83
CHEMBL4065312 EC50 = 1610.0 nM 5.79
CHEMBL141 LAMIVUDINE EC50 = 2540.0 nM 5.59
CHEMBL4083944 EC50 = 4920.0 nM 5.31
CHEMBL4102225 EC50 = 6080.0 nM 5.22
CHEMBL4102339 EC50 = 6210.0 nM 5.21
CHEMBL4073925 EC50 = 7520.0 nM 5.12
CHEMBL4086744 EC50 = 39400.0 nM 4.41
CHEMBL4081492 EC50 = 47000.0 nM 4.33
CHEMBL4097074 EC50 = 48900.0 nM 4.31
CHEMBL1460 DIDANOSINE EC50 = 76000.0 nM 4.12
CHEMBL4094486 EC50 >= 9050.0 nM -
CHEMBL4076724 EC50 > 54700.0 nM -
CHEMBL4059524 EC50 > 115000.0 nM -
CHEMBL4064287 EC50 > 30000.0 nM -
CHEMBL4092014 EC50 > 11500.0 nM -
CHEMBL4070909 EC50 > 4400.0 nM -
CHEMBL4084260 EC50 > 62200.0 nM -
CHEMBL4064984 EC50 > 28600.0 nM -
CHEMBL4086444 EC50 > 5060.0 nM -
CHEMBL4091707 EC50 > 28000.0 nM -
CHEMBL4063941 EC50 > 6120.0 nM -
CHEMBL4098005 EC50 > 17400.0 nM -
CHEMBL4101937 EC50 > 93400.0 nM -