Assay Detail
Binding
CHEMBL4057091
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Inhibition of bovine xanthine oxidase assessed as reduction in uric acid production using xanthine as substrate preincubated for 10 mins followed by substrate addition by spectrophotometric analysis
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of 1-phenyl-1H-1,2,3-triazole-4-carboxylic acid derivatives as xanthine oxidase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 5.81 | 7.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL169526 | — | — | 1 | 7.80 |
| CHEMBL4088219 | — | — | 1 | 6.68 |
| CHEMBL4104394 | — | — | 1 | 6.20 |
| CHEMBL4096868 | — | — | 1 | 6.14 |
| CHEMBL4080364 | — | — | 1 | 6.12 |
| CHEMBL4069651 | — | — | 1 | 6.07 |
| CHEMBL4077721 | — | — | 1 | 6.03 |
| CHEMBL4066322 | — | — | 1 | 5.97 |
| CHEMBL4071841 | — | — | 1 | 5.83 |
| CHEMBL4096672 | — | — | 1 | 5.82 |
| CHEMBL4071469 | — | — | 1 | 5.79 |
| CHEMBL4096481 | — | — | 1 | 5.62 |
| CHEMBL4066958 | — | — | 1 | 5.54 |
| CHEMBL4061387 | — | — | 1 | 5.49 |
| CHEMBL4104593 | — | — | 1 | 5.47 |
| CHEMBL4061512 | — | — | 1 | 5.40 |
| CHEMBL4093939 | — | — | 1 | 5.30 |
| CHEMBL4094828 | — | — | 1 | 5.21 |
| CHEMBL1467 | ALLOPURINOL | 4.0 | 1 | 5.12 |
| CHEMBL4078654 | — | — | 1 | 4.58 |
| CHEMBL4067379 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL169526 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL4088219 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL4104394 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL4096868 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL4080364 | — | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL4069651 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL4077721 | — | IC50 | = | 940.0 | nM | 6.03 |
| CHEMBL4066322 | — | IC50 | = | 1080.0 | nM | 5.97 |
| CHEMBL4071841 | — | IC50 | = | 1470.0 | nM | 5.83 |
| CHEMBL4096672 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL4071469 | — | IC50 | = | 1620.0 | nM | 5.79 |
| CHEMBL4096481 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL4066958 | — | IC50 | = | 2850.0 | nM | 5.54 |
| CHEMBL4061387 | — | IC50 | = | 3270.0 | nM | 5.49 |
| CHEMBL4104593 | — | IC50 | = | 3350.0 | nM | 5.47 |
| CHEMBL4061512 | — | IC50 | = | 3960.0 | nM | 5.40 |
| CHEMBL4093939 | — | IC50 | = | 5030.0 | nM | 5.30 |
| CHEMBL4094828 | — | IC50 | = | 6240.0 | nM | 5.21 |
| CHEMBL1467 | ALLOPURINOL | IC50 | = | 7560.0 | nM | 5.12 |
| CHEMBL4078654 | — | IC50 | = | 26130.0 | nM | 4.58 |
| CHEMBL4067379 | — | IC50 | > | 30000.0 | nM | - |