Assay Detail
Binding
CHEMBL4058231
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-(+)-U69,593 from KOR in guinea pig brain membranes by liquid scintillation counting analysis
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Development of novel LP1-based analogues with enhanced delta opioid receptor profile.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 7.53 | 8.65 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4079574 | — | — | 1 | 8.65 |
| CHEMBL4066846 | — | — | 1 | 8.14 |
| CHEMBL4077833 | — | — | 1 | 7.98 |
| CHEMBL4102093 | — | — | 1 | 7.82 |
| CHEMBL3759092 | — | — | 1 | 6.96 |
| CHEMBL4060120 | — | — | 1 | 5.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4079574 | — | Ki | = | 2.22 | nM | 8.65 |
| CHEMBL4066846 | — | Ki | = | 7.3 | nM | 8.14 |
| CHEMBL4077833 | — | Ki | = | 10.51 | nM | 7.98 |
| CHEMBL4102093 | — | Ki | = | 15.22 | nM | 7.82 |
| CHEMBL3759092 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL4060120 | — | Ki | = | 2276.0 | nM | 5.64 |