Assay Detail
Binding
CHEMBL4059046
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Binding affinity to human full length recombinant His-tagged HuR expressed in Escherichia coli Rosetta DH5alpha assessed as inhibition of interaction with single-strand Bi-AU RNA probe by AlphaScreen assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Interfering with HuR-RNA Interaction: Design, Synthesis and Biological Characterization of Tanshinone Mimics as Novel, Effective HuR Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 17 | 7.42 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4075458 | — | — | 1 | 7.89 |
| CHEMBL4064932 | — | — | 1 | 7.82 |
| CHEMBL4095060 | — | — | 1 | 7.39 |
| CHEMBL4100171 | — | — | 1 | 7.32 |
| CHEMBL227075 | DIHYDROTANSHINONE I | — | 1 | 7.30 |
| CHEMBL4105230 | — | — | 1 | 7.26 |
| CHEMBL4073526 | — | — | 1 | 7.25 |
| CHEMBL4094161 | — | — | 1 | 7.09 |
| CHEMBL4067653 | — | — | 1 | - |
| CHEMBL4102819 | — | — | 1 | - |
| CHEMBL4092808 | — | — | 1 | - |
| CHEMBL4081086 | — | — | 1 | - |
| CHEMBL4075620 | — | — | 1 | - |
| CHEMBL4077265 | — | — | 1 | - |
| CHEMBL4076484 | — | — | 1 | - |
| CHEMBL4070465 | — | — | 1 | - |
| CHEMBL4073683 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4075458 | — | Ki | = | 12.8 | nM | 7.89 |
| CHEMBL4064932 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL4095060 | — | Ki | = | 41.0 | nM | 7.39 |
| CHEMBL4100171 | — | Ki | = | 48.0 | nM | 7.32 |
| CHEMBL227075 | DIHYDROTANSHINONE I | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL4105230 | — | Ki | = | 55.0 | nM | 7.26 |
| CHEMBL4073526 | — | Ki | = | 56.0 | nM | 7.25 |
| CHEMBL4094161 | — | Ki | = | 81.0 | nM | 7.09 |
| CHEMBL4067653 | — | Ki | > | 100.0 | nM | - |
| CHEMBL4102819 | — | Ki | > | 100.0 | nM | - |
| CHEMBL4092808 | — | Ki | > | 100.0 | nM | - |
| CHEMBL4081086 | — | Ki | > | 100.0 | nM | - |
| CHEMBL4075620 | — | Ki | > | 200.0 | nM | - |
| CHEMBL4077265 | — | Ki | > | 200.0 | nM | - |
| CHEMBL4076484 | — | Ki | > | 100.0 | nM | - |
| CHEMBL4070465 | — | Ki | > | 200.0 | nM | - |
| CHEMBL4073683 | — | Ki | > | 300.0 | nM | - |