Assay Detail
Functional
CHEMBL4059189
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Growth inhibition of human MV4-11 cells after 72 hrs by CellTiter-Glo assay
39
Total Activities
39
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MV4-11 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of 4-((7H-Pyrrolo[2,3-d]pyrimidin-4-yl)amino)-N-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-1H-pyrazole-3-carboxamide (FN-1501), an FLT3- and CDK-Kinase Inhibitor with Potentially High Efficiency against Acute Myelocytic Leukemia.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 39 | 7.63 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1336 | SORAFENIB | 4.0 | 1 | 8.40 |
| CHEMBL4093906 | — | — | 1 | 8.15 |
| CHEMBL4077071 | — | — | 1 | 8.10 |
| CHEMBL4080236 | — | — | 1 | 7.96 |
| CHEMBL4092761 | — | — | 1 | 7.92 |
| CHEMBL4076277 | — | — | 1 | 7.89 |
| CHEMBL4099013 | — | — | 1 | 7.82 |
| CHEMBL4073053 | — | — | 1 | 7.77 |
| CHEMBL4071450 | — | — | 1 | 7.77 |
| CHEMBL4104057 | — | — | 1 | 7.72 |
| CHEMBL4075720 | — | — | 1 | 7.72 |
| CHEMBL4078261 | — | — | 1 | 7.68 |
| CHEMBL4103390 | — | — | 1 | 7.68 |
| CHEMBL4061686 | — | — | 1 | 7.64 |
| CHEMBL4088753 | — | — | 1 | 7.64 |
| CHEMBL4096307 | — | — | 1 | 7.57 |
| CHEMBL4086149 | — | — | 1 | 7.54 |
| CHEMBL4073283 | — | — | 1 | 7.52 |
| CHEMBL4075723 | — | — | 1 | 7.47 |
| CHEMBL4077278 | — | — | 1 | 7.46 |
| CHEMBL4101635 | — | — | 1 | 7.33 |
| CHEMBL4074948 | — | — | 1 | 7.28 |
| CHEMBL4098796 | — | — | 1 | 6.63 |
| CHEMBL4078605 | — | — | 1 | 6.35 |
| CHEMBL4064488 | — | — | 1 | - |
| CHEMBL4086011 | — | — | 1 | - |
| CHEMBL4067804 | — | — | 1 | - |
| CHEMBL4066619 | — | — | 1 | - |
| CHEMBL4077074 | — | — | 1 | - |
| CHEMBL4075466 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1336 | SORAFENIB | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4093906 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL4077071 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL4080236 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL4092761 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4076277 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL4099013 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL4073053 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL4071450 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL4104057 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL4075720 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL4078261 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL4103390 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL4061686 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL4088753 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL4096307 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL4086149 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL4073283 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL4075723 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL4077278 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL4101635 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL4074948 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL4098796 | — | IC50 | = | 232.0 | nM | 6.63 |
| CHEMBL4078605 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL4093755 | — | IC50 | > | 0.15 | nM | - |
| CHEMBL4103338 | — | IC50 | - | — | - | |
| CHEMBL4076183 | — | IC50 | - | — | - | |
| CHEMBL4075982 | — | IC50 | - | — | - | |
| CHEMBL4064843 | — | IC50 | - | — | - | |
| CHEMBL4061687 | — | IC50 | - | — | - | |
| CHEMBL4097755 | — | IC50 | - | — | - | |
| CHEMBL4059849 | — | IC50 | - | — | - | |
| CHEMBL4088115 | — | IC50 | - | — | - | |
| CHEMBL4075466 | — | IC50 | - | — | - | |
| CHEMBL4077074 | — | IC50 | - | — | - | |
| CHEMBL4066619 | — | IC50 | - | — | - | |
| CHEMBL4067804 | — | IC50 | - | — | - | |
| CHEMBL4086011 | — | IC50 | - | — | - | |
| CHEMBL4064488 | — | IC50 | - | — | - |