Assay Detail
Functional
CHEMBL4118528
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Antiproliferative activity against mouse BA/F3 cells harboring NRAS G12D mutant after 72 hrs in presence of IL-3 by CellTiter-Glo assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | BaF3 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Studies of TAK1-centered polypharmacology with novel covalent TAK1 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.58 | 7.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3884960 | — | — | 1 | 7.21 |
| CHEMBL4128584 | — | — | 1 | 6.75 |
| CHEMBL3884642 | — | — | 1 | 6.56 |
| CHEMBL3884229 | — | — | 1 | 6.41 |
| CHEMBL3884143 | — | — | 1 | 5.99 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3884960 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL4128584 | — | IC50 | = | 178.0 | nM | 6.75 |
| CHEMBL3884642 | — | IC50 | = | 277.0 | nM | 6.56 |
| CHEMBL3884229 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL3884143 | — | IC50 | = | 1015.0 | nM | 5.99 |