Assay Detail
Functional
CHEMBL4119112
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Cytotoxicity against human A431 cells assessed as reduction in cell viability after 5 days by MTT assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A-431 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Preussilides A-F, Bicyclic Polyketides from the Endophytic Fungus Preussia similis with Antiproliferative Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.55 | 10.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 10.14 |
| CHEMBL4126187 | — | — | 1 | 5.00 |
| CHEMBL4127726 | — | — | 1 | 4.75 |
| CHEMBL4127416 | — | — | 1 | 4.69 |
| CHEMBL4128814 | — | — | 1 | 4.46 |
| CHEMBL4129629 | — | — | 1 | 4.25 |
| CHEMBL4126336 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL94657 | PATUPILONE | IC50 | = | 0.073 | nM | 10.14 |
| CHEMBL4126187 | — | IC50 | = | 10100.0 | nM | 5.00 |
| CHEMBL4127726 | — | IC50 | = | 17900.0 | nM | 4.75 |
| CHEMBL4127416 | — | IC50 | = | 20300.0 | nM | 4.69 |
| CHEMBL4128814 | — | IC50 | = | 35100.0 | nM | 4.46 |
| CHEMBL4129629 | — | IC50 | = | 55800.0 | nM | 4.25 |
| CHEMBL4126336 | — | IC50 | > | 2437500.0 | nM | - |