Assay Detail
ADMET
CHEMBL4119595
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]prazosin from alpha1 adrenoceptor in C57BL/6 mouse hippocampal homogenates after 40 mins by liquid scintillation counting method
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Mus musculus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Intermediate |
Publication
Evaluation of the antidepressant therapeutic potential of isocyanine and pseudoisocyanine analogues of the organic cation decynium-22.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.80 | 8.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL836 | TAMSULOSIN | 4.0 | 1 | 8.74 |
| CHEMBL4129927 | — | — | 1 | 7.22 |
| CHEMBL4126353 | — | — | 1 | 6.46 |
| CHEMBL4126498 | — | — | 1 | 6.24 |
| CHEMBL4129778 | — | — | 1 | 6.15 |
| CHEMBL4128701 | — | — | 1 | 5.97 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL836 | TAMSULOSIN | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL4129927 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL4126353 | — | IC50 | = | 348.0 | nM | 6.46 |
| CHEMBL4126498 | — | IC50 | = | 577.0 | nM | 6.24 |
| CHEMBL4129778 | — | IC50 | = | 711.0 | nM | 6.15 |
| CHEMBL4128701 | — | IC50 | = | 1066.0 | nM | 5.97 |