Assay Detail
Functional
CHEMBL4119644
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Antiproliferative activity against human HCT15 cells after 48 hrs by MTT assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-15 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis of thiazole linked indolyl-3-glyoxylamide derivatives as tubulin polymerization inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 5.89 | 7.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL61 | PODOFILOX | 4.0 | 1 | 7.21 |
| CHEMBL4126148 | — | — | 1 | 6.75 |
| CHEMBL4128220 | — | — | 1 | 5.60 |
| CHEMBL4127954 | — | — | 1 | 4.99 |
| CHEMBL4127243 | — | — | 1 | 4.90 |
| CHEMBL4127384 | — | — | 1 | - |
| CHEMBL4127666 | — | — | 1 | - |
| CHEMBL4128628 | — | — | 1 | - |
| CHEMBL4125747 | — | — | 1 | - |
| CHEMBL4128913 | — | — | 1 | - |
| CHEMBL4126147 | — | — | 1 | - |
| CHEMBL4128255 | — | — | 1 | - |
| CHEMBL4129449 | — | — | 1 | - |
| CHEMBL4126308 | — | — | 1 | - |
| CHEMBL4129049 | — | — | 1 | - |
| CHEMBL4127151 | — | — | 1 | - |
| CHEMBL4129035 | — | — | 1 | - |
| CHEMBL4126045 | — | — | 1 | - |
| CHEMBL4130247 | — | — | 1 | - |
| CHEMBL4125835 | — | — | 1 | - |
| CHEMBL4127194 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL61 | PODOFILOX | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL4126148 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL4128220 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL4127954 | — | IC50 | = | 10300.0 | nM | 4.99 |
| CHEMBL4127243 | — | IC50 | = | 12500.0 | nM | 4.90 |
| CHEMBL4127384 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4127666 | — | IC50 | - | — | - | |
| CHEMBL4128628 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4125747 | — | IC50 | - | — | - | |
| CHEMBL4128913 | — | IC50 | - | — | - | |
| CHEMBL4126147 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4128255 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4129449 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4126308 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4129049 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4127151 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4129035 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4126045 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4130247 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4125835 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4127194 | — | IC50 | > | 50000.0 | nM | - |